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292605-14-2

292605-14-2 Structure

292605-14-2 Structure
IdentificationBack Directory
[Name]

MMP-2/MMP-9 INHIBITOR IV
[CAS]

292605-14-2
[Molecular Formula]

C15H14O3S2
[MDL Number]

MFCD03457520
Chemical PropertiesBack Directory
[storage temp. ]

?20°C
[solubility ]

DMSO: >20mg/mL
[form ]

powder
[color ]

white to off-white
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36
[Safety Statements ]

26
[WGK Germany ]

3
[HS Code ]

29349990
Hazard InformationBack Directory
[Uses]

Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206μM for MMP-1, 15μM for MMP-3, 96μM for MMP-7, and 4μM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.
[Enzyme inhibitor]

This thiirane (FW = 306.41 g/mol), also known as matrix metalloproteinase-2/matrix metalloproteinase-9 inhibitor IV (MMP- 2/MMP-9 inhibitor IV) and SB-3CT, is a mechanism-based inhibitor of gelatinase A, or matrux metalloproteinase 2, Ki = 0.014 μM, gelatinase B, or matrix metalloproteinase 9, Ki = 0.6 μM, membrane-type matrix metalloproteinase 1, matrix metalloproteinase 14, matrilysin, Ki = 96 μM, stromelysin 1, or matrix metalloproteinase 3, Ki = 15 μM.
Spectrum DetailBack Directory
[Spectrum Detail]

MMP-2/MMP-9 INHIBITOR IV(292605-14-2)1HNMR
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