| Identification | Back Directory | [Name]
SB 269970 HYDROCHLORIDE | [CAS]
201038-74-6 | [Synonyms]
CS-776
SB269970HCl
SB-269970;SB 269970
SB 269970 HYDROCHLORIDE
(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol
Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-
(R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine
Pyrrolidine, 1-((3-hydroxyphenyl)sulfonyl)-2-(2-(4-methyl-1-piperidinyl)ethyl)-, (R)-
(2R)-1-[(3-HYDROXYPHENYL)SULFONYL]-2-[2-(4-METHYL-1-PIPERIDINYL)ETHYL]PYRROLIDINE HYDROCHLORIDE | [Molecular Formula]
C18H28N2O3S | [MDL Number]
MFCD03788020 | [MOL File]
201038-74-6.mol | [Molecular Weight]
352.49 |
| Chemical Properties | Back Directory | [Boiling point ]
512.9±56.0 °C(Predicted) | [density ]
1.188 | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
H2O: 22 mg/mL
| [form ]
solid
| [pka]
8.88±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SB 269970 is a selective and potent SR-7 antagonist. | [Definition]
ChEBI: 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]phenol is a sulfonamide. | [Biological Activity]
Potent and selective 5-HT 7 receptor antagonist (pK i values are 8.9, 7.2 and 6.0 for 5-HT 7A , 5-HT 5A and 5-HT 1B and < 6.0 for 5-HT 1A , 5-HT 1D , 5-HT 1E , 5-HT 1F , 5-HT 2A , 5-HT 2B , 5-HT 2C , 5-HT 4 and 5-HT 6 receptors respectively). Brain penetrant in vivo . | [in vivo]
SB-269970 (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity[2]. | Animal Model: | Male C57BL6/J mice[2] | | Dosage: | 3, 10, 30 mg/kg | | Administration: | Intraperitoneal injection; once | | Result: | Significantly blocked amphetamine and ketamine-induced hyperactivity. |
| [IC 50]
Human 5-HT7 Receptor: 8.3 (pKi) | [storage]
Store at -20°C |
|
| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
BePharm Ltd
|
| Tel: |
400-685-9117 |
| Website: |
www.bepharm.com |
|