| Identification | Back Directory | [Name]
AC-LEU-GLU-HIS-ASP-AMC | [CAS]
292633-16-0 | [Synonyms]
AC-LEHD-MCA
AC-LEHD-AMC
PASE-9SUBSTRATE
AC-LEU-GLU-HIS-ASP-MCA
AC-LEU-GLU-HIS-ASP-AMC
CASPASE-9 SUBSTRATE (FLUOROGENIC)
AC-LEHD-AMC TRIFLUOROACETATE SALT
AC-LEU-GLU-HIS-ASP-7-AMINO-4-METHYLCOUMARIN
CASPASE-9 SUBSTRATE ;AC-LEU-GLU-HIS-ASP-AMC
AC-LEU-GLU-HIS-ASP-AMC TRIFLUOROACETATE SALT
N-Acetyl-Leu-Glu-His-Asp-7-amino-4-methylcoumarin
N-ACETYL-LEU-GLU-HIS-ASP-7-AMINO-4-METHYLCOUMARIN AMC
ACETYL-L-LEUCYL-L-GLUTAMYL-L-HISTIDYL-L-ASPARTIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE)
N-Acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine
L-α-Asparagine, N-acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- | [Molecular Formula]
C33H41N7O11 | [MDL Number]
MFCD01862664 | [MOL File]
292633-16-0.mol | [Molecular Weight]
711.72 |
| Chemical Properties | Back Directory | [Boiling point ]
1258.1±65.0 °C(Predicted) | [density ]
1.388±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
Water: 1 mg/ml | [form ]
Lyophilized Powder | [pka]
4.07±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
1mg/mL in water |
| Hazard Information | Back Directory | [Description]
Ac-LEHD-AMC is a fluorogenic substrate for caspase-9. Ac-LEHD-AMC is cleaved by caspase-9 to release the fluorescent moiety AMC, which can be used to quantify caspase-9 activity. | [Uses]
Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity[1]. | [References]
[1] Igor M Prudnikov, et al. Short peptide tools for monitoring caspase and proteasome activities in embryonal and adult rat brain lysates: an approach for the differential identification of proteases. J Biochem. 2012 Mar;151(3):299-316. DOI:10.1093/jb/mvs001 | [Sequene]
Ac-Leu-Glu-His-Asp-AMC |
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