| Identification | Back Directory | [Name]
t-Boc-N-Amido-PEG2-Ms | [CAS]
302331-20-0 | [Synonyms]
Boc-N-PEG2-Ms
Boc-NH-PEG2-Ms
Boc-N-PEG2-Oms
t-Boc-N-Amido-PEG2-Ms
2-(2-((tert-Butoxycarbonyl)amino)ethoxy)ethyl methanesulfonate | [Molecular Formula]
C10H21NO6S | [MDL Number]
MFCD24465573 | [MOL File]
302331-20-0.mol | [Molecular Weight]
283.34 |
| Chemical Properties | Back Directory | [Boiling point ]
439.8±30.0 °C(Predicted) | [density ]
1.182±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
12.18±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
t-Boc-N-Amido-PEG2-Ms is a PEG linker that contains a Boc protecting group and a mesyl group. The t-Boc group can be removed under acidic conditions. The mesyl group is a good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases the water solubility of the compound. Longer PEG chains increase the water solubility properties of the compound. | [Uses]
Boc-N-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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