| Identification | Back Directory | [Name]
t-Boc-N-amido-PEG1-acid | [CAS]
1260092-44-1 | [Synonyms]
Boc-NH-PEG1-COOH
Boc-N-amido-PEG1-acid
Boc-NH-PEG1-CH2CH2COOH
t-Boc-N-amido-PEG1-acid
t-boc-N-amido-PEG1-propionic acid
3-[2-(Boc-amino)ethoxy]propanoic acid
3-(2-T-BOC-AMINOETHOXY)PROPANOIC ACID
3-(2-((tert-Butoxycarbonyl)amino)ethoxy)propanoic acid
Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]- | [Molecular Formula]
C10H19NO5 | [MDL Number]
MFCD22574796 | [MOL File]
1260092-44-1.mol | [Molecular Weight]
233.26 |
| Chemical Properties | Back Directory | [Boiling point ]
385.0±27.0 °C(Predicted) | [density ]
1.127±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
4.29±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
t-Boc-N-amido-PEG1-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Biological Activity]
Boc-NH-PEG1-CH2CH2COOH is a cleavable ADC linker containing 1 unit PEG, and also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used for the synthesis of antibody-drug conjugates (ADC) and PROTACs . | [target]
| PEGs | Alkyl/ether | Cleavable | |
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