| Identification | Back Directory | [Name]
t-Boc-N-Amido-PEG2-Propargyl | [CAS]
869310-84-9 | [Synonyms]
Propargyl-PEG2-NHBoc
t-Boc-N-Amido-PEG2-Propargyl
tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate | [Molecular Formula]
C12H21NO4 | [MDL Number]
MFCD22418469 | [MOL File]
869310-84-9.mol | [Molecular Weight]
243.3 |
| Chemical Properties | Back Directory | [Boiling point ]
344.2±27.0 °C(Predicted) | [density ]
1.033±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
12.22±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
t-Boc-N-Amido-PEG2-propargyl is crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-Boc protected amine can be deprotected under mild acidic conditions. | [Uses]
Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cleavable Linker; PEGs; Alkyl/ether | [References]
[1] Nello Mainolfi, et al. rak degraders and uses thereof. US20190192668A1. |
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