| Identification | More | [Name]
Flunarizine dihydrochloride | [CAS]
30484-77-6 | [Synonyms]
1-(BIS[4-FLUOROPHENYL]) DIHYDROCHLORIDE
1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)PIPERAZINE 2 HCL
1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLO RIDE
(E)-1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)PIPERAZINE DIHYDROCHLORIDE
FLUNARIZINE 2HCL
FLUNARIZINE DIHYDROCHLORIDE
FLUNARIZINE HCL
FLUNARIZINE HYDROCHLORIDE
(e)-1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazinedihydroch
(e)-1-(bis(p-fluorophenyl)methyl)-4-cinnamylpiperazinedihydrochloride
1-(bis(p-fluorophenyl)methyl)-4-cinnamyl-,dihydrochloride,(e)-piperazin
kw-3149
r14950
Flunarizine, DiHCl
(E)-1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride
FLUNARIZINE DIHYDROCHLORIDE CA2+/NA+ CHA NNEL ANTA
FLUNARIZIN-DIHYDROCHLORIDE
FLUNARIZINE HYDROCHLORIDE EPF(CRM STANDARD)
Flugeral
Flunarl | [EINECS(EC#)]
250-216-6 | [Molecular Formula]
C26H28Cl2F2N2 | [MDL Number]
MFCD00058198 | [Molecular Weight]
477.42 | [MOL File]
30484-77-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
188-190?C | [storage temp. ]
2-8°C
| [solubility ]
chloroform/methanol (9:1): 50 mg/mL, clear, colorless
| [form ]
neat | [color ]
White to Off-White | [Merck ]
13,4170 | [BRN ]
4284243 | [InChI]
InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;; | [InChIKey]
RXKMOPXNWTYEHI-RDRKJGRWSA-N | [SMILES]
C(C1C=CC(F)=CC=1)(C1=CC=C(F)C=C1)N1CCN(C/C=C/C2C=CC=CC=2)CC1.Cl.Cl | [CAS DataBase Reference]
30484-77-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [WGK Germany ]
3
| [RTECS ]
TK9187000
| [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Originator]
Sibelium,Janssen,W. Germany,1977 | [Uses]
antipsychotic, H1 antihistamine | [Uses]
Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog. | [Definition]
ChEBI: Flunarizine hydrochloride is a diarylmethane. | [Manufacturing Process]
A mixture of 14.3 parts of di-(p-fluorophenyl)-chloromethane, 10.1 parts of 1-
cinnamylpiperazine, 12.7 parts of sodium carbonate, a few crystals of
potassium iodide in 200 parts of 4-methyl-2-pentanone is stirred and refluxed
for 21 hours. The reaction mixture is cooled and 50 parts of water are added.
The organic layer is separated, dried, filtered and evaporated.
The oily residue is dissolved in 480 parts of anhydrous diisopropyl ether. This
solution is boiled with activated charcoal, filtered and to the clear filtrate is
added an excess of 2-propanol, previously saturated with gaseous hydrogen
chloride. The precipitated salt is filtered off and recrystallized from a mixture
of 2-propanol and ethanol, yielding 1-cinnamyl-4-(di-p-fluorobenzhydryl)
piperazine dihydrochloride, MP 251.5°C. | [Therapeutic Function]
Vasodilator | [General Description]
Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo. | [Biological Activity]
Dual Na + /Ca 2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective. | [Biochem/physiol Actions]
Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells | [storage]
Store at -20°C |
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