| Identification | Back Directory | [Name]
ACETYL COENZYME A (C2:0) LITHIUM | [CAS]
32140-51-5 | [Synonyms]
Acetyl-CoA (lithium salt)
Acetyl-CoA, Acetyl-S-CoA Li3
ACETYL COENZYME A (C2:0) LITHIUM
Coenzyme A, S-acetate,lithium salt (8CI,9CI)
Acetyl coenzyme A trilithium salt,Acetyl-S-CoA Li3
adenosine, 5'-O-[[[[[(3R)-4-[[3-[[2-(acetylthio)ethyl]amino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl]oxy]hydroxyphosphinyl]oxy]hydroxyphosphinyl]-, 3'-(dihydrogen phosphate), trilithium salt | [Molecular Formula]
C23H39LiN7O17P3S | [MDL Number]
MFCD00167406 | [MOL File]
32140-51-5.mol | [Molecular Weight]
817.52 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: soluble100mg/mL, clear, colorless | [form ]
powder | [color ]
White to off-white | [Water Solubility ]
H2O: soluble 100mg/mL, clear, colorless | [Stability:]
Hygroscopic | [InChIKey]
FTRFBNATWBKIQU-JHJDYNLLSA-K | [SMILES]
[Li+].[Li+].[Li+].CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23 |
| Hazard Information | Back Directory | [Uses]
Acetyl coenzyme A is suitable in CAT reporter assay for the measurement of chloramphenicol acetyltransferase by incubating the cell extract with 0.1 μCi [14C] chloramphenicol and 0.5mM acetyl-CoA. | [Biochem/physiol Actions]
Alterations in the gene encoding acetyl-CoA have been linked to Alzheimer′s disease and mild cognitive impairment. Defects in the gene cause myasthenic syndrome associated with episodic apnea. | [in vivo]
Acetyl coenzyme A lithium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy[2][3].
Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A lithium levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A lithium concentrations in the brain and actually increase hepatic Acetyl coenzyme A lithium and protein acetylation levels[4]. | [IC 50]
Human Endogenous Metabolite |
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