| Identification | Back Directory | [Name]
Anticholinesterase | [CAS]
9000-81-1 | [Synonyms]
ACHE
AcCholE
EC 3.1.1.7
Cholinesterase I
ANTICHOLINESTERASE
TRUE CHOLINESTERASE
ACETYLCHOLINESTERASE
Acetylcholinesterases
CHOLINESTERASE, ACETYL
ACETYLCHOLINE ESTERASE
Acetylcholine hydrolase
Acetylthiocholinesterase
Esterase, acetyl choline
TRUE CHOLINESTERASE HUMAN
acetylcholinesterase human
Cholinesterase,BeefPancreas
Acetylcholinesterase (AChE)
Acetylcholinesterase-Agarose
TRUE CHOLINESTERASE TYPE V-S
Acetylcholinesterase, 200u/g
CHOLINESTERASE, ACETYL HUMAN
TRUE CHOLINESTERASE TYPE VI-S
ACETYLCHOLINE ACETYLHYDROLASE
TRUE CHOLINESTERASE TYPE XII-S
CHOLINESTERASE ACETYL TYPE III
CHOLINESTERASE, ACETYL TYPE V-S
CHOLINESTERASE, ACETYL TYPE VI-S
Acetyl beta-methylcholinesterase
ACETYLCHOLINESTERASE FROM ELECTRO
CHOLINESTERASE, ACETYL TYPE XII-S
ACETYLCHOLINE ACETYLHYDROLASE HUMAN
AcetylcholinesteraseExBovineErythro-
Acetylcholine acetylhydrolase, AChE
Acetylcholinesterase from electric eel
ACETYLCHOLINE ACETYLHYDROLASE TYPE V-S
ACETYLCHOLINE ACETYLHYDROLASE TYPE VI-S
ACETYLCHOLINESTERASE TYPE III ELECTRIC
CHOLINESTERASE, ACETYL HUMANRECOMBINANT
Esterase, acetylcholine (ELECTRIC EEL)
Acetylcholinesterase Human, Recombinant
ACETYLCHOLINE ESTERASE F. ELECTROPHORUS&
ACETYLCHOLINESTERASE TYPE XII-S BOVINE
ACETYLCHOLINE ACETYLHYDROLASE TYPE XII-S
Acetylcholinesterasefrombovineerythrocytes
acetylcholinesterase from human erythrocytes
Native Human erythrocytes Acetylcholinesterase
Acetylcholinesterase from electric eel, 200u/g
ACETYL CHOLINESTERASE TYPE V-S FROM ELECTRIC EEL
CHOLINESTERASE, ACETYL TYPE V-SFROM ELEC TRIC EEL
CHOLINESTERASE, ACETYL TYPE VI-S FROMELE CTRIC EEL
CHOLINESTERASE, ACETYL AMPHIPHILIC FROM HUMAN ERYTH
CHOLINESTERASE ACETYL TYPE XIIIFROM HUMA N ERYTHROC
ACETYLCHOLINE ESTERASE F. ELECTROPHORUS ELECT., ~850 U/MG
Acetylcholine esterase from bovine erythrocytes, lyophil.
ACETYLCHOLINE ESTERASE MEMBR.B. F. BOV. ERYTHROC. ~400U/MG*
Acetylcholinesterase human,AChE, Acetylcholine acetylhydrolase
Acetylcholine acetylhydrolase, AChE, Cholinesterase, Acetyl
acetylcholinesterase from electrophorus electricus (electric eel)
Native Electrophorus electricus (electric eel) Acetylcholinesterase
Acetylcholinesterase from human erythrocytes,AChE, Acetylcholine acetylhydrolase
Acetylcholine acetylhydrolase, AChE, Acetylcholine Esterase, membrane-bound, from bovine erythrocytes
Acetylcholinesterase from Electrophorus electricus (electric eel),AChE, Acetylcholine acetylhydrolase, Cholinesterase, Acetyl | [EINECS(EC#)]
232-559-3 | [Molecular Formula]
NULL | [MDL Number]
MFCD00081268 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: 1 mg/mL
| [form ]
powder
| [color ]
slightly yellow
| [biological source]
human erythrocytes | [Specific Activity]
200-1,000units/mg protein | [Major Application]
diagnostic assay manufacturing |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS08 | [Signal word ]
Danger | [Hazard statements ]
H334 | [Precautionary statements ]
P261-P285-P304+P341-P342+P311-P501 | [Hazard Codes ]
B | [WGK Germany ]
3
| [F ]
10-21 | [Storage Class]
11 - Combustible Solids | [Toxicity]
The inhibition of AChE by these anticholinesterases leads to an accumulation of
endogenous ACh, and thus results in hyperactivation of cholinergic
receptors. Signs of acute poisoning can include irritability,
tremors, convulsions, and predominately parasympathetic
effects, with death usually the result of respiratory failure.
Since AChE is contained in erythrocytes, the assay of erythrocyte
AChE activity can be used as a diagnostic tool to assess
exposure to organophosphorus anticholinesterases. |
| Hazard Information | Back Directory | [Uses]
Pesticides. | [Definition]
Any substance that inhibits or inactivates acetylcholinesterase, thereby preventing the hydrolysis of acetylcholine. Their action leads to an accumulation of endogenous acetylcholine with a resultant hyperactivity of cholinergic neurons, which can prove lethal. | [General Description]
Predominantly exists as a tetrameric glycoprotein composed of disulfide-linked homodimers with a monomer MW of ~80 kDa. | [Hazard]
Tremors; convulsions; respiratory failure; death. | [Biochem/physiol Actions]
Acetylcholinesterase (AChE) is regarded as a biomarker in neurotoxicity. It is a modulator of nitric oxide signal transduction pathway and marker of membrane integrity and aging. The levels of erythrocyte (RBC) AChE are affected on pesticide exposure and in hemolytic anemia. RBC AChE is a marker in Hirschsprung′s disease and inflammation. |
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