| Identification | More | [Name]
Difenidol hydrochloride | [CAS]
3254-89-5 | [Synonyms]
1,1-diphenyl-4-(1-piperidyl)butan-1-ol hydrochloride
1,1-DIPHENYL-4-PIPERIDINO-1-BUTANOL HYDROCHLORIDE
1-(4-HYDROXY-4,4-DIPHENYLBUTYL)PIPERIDINE HYDROCHLORIDE
DIFENIDOL
DIFENIDOL HYDROCHLORIDE
DIPHENIDOL
DIPHENIDOL HYDROCHLORIDE
LABOTEST-BB LT00771934
TIMTEC-BB SBB006449
alpha,alpha-diphenyl-1-piperidinebutanohydrochloride
alpha,alpha-diphenyl-1-piperidinebutanolhydrochloride
cefadol
celmidol
difenidolin
maniol
mecalmin
pineroro
satanolon
tenesdol
wansar | [EINECS(EC#)]
221-850-0 | [Molecular Formula]
C21H27NO | [MDL Number]
MFCD00057378 | [Molecular Weight]
309.45 | [MOL File]
3254-89-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
212-214° | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly, Sonicated), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [PH]
pH (10g/l, 25℃) : 4.7～6.5 | [Water Solubility ]
H2O: 2mg/mL, clear (warmed) | [Merck ]
3311 | [InChI]
InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2 | [InChIKey]
OGAKLTJNUQRZJU-UHFFFAOYSA-N | [SMILES]
C(O)(CCCN1CCCCC1)(C1=CC=CC=C1)C1C=CC=CC=1 | [CAS DataBase Reference]
3254-89-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
TM4970500
| [HS Code ]
2933.39.9200 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral | [Toxicity]
LD50 oral in rat: 515mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Diphenidol is an muscarinic antagonist is an antivertigo agent. Diphenidol displays heart arrhythmia inhibition and parasympatholytic activity. | [Definition]
ChEBI: Difenidol hydrochloride is a diarylmethane. | [Brand name]
Vontrol (GlaxoSmithKline). | [Biological Activity]
Diphenidol is a non-selective muscarinic acetylcholine receptor antagonist. Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. | [Synthesis]
Difenidol hydrochloride is synthesized in three steps. S1: Preparation of 1-(3-chloropropyl)hexahydropyridine: 1,3-Bromochloropropane reacts with hexahydropyridine at room temperature. Liquid base is then added. After layering, the oily layer is collected |
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