| Identification | More | [Name]
2-FLUORO-4-NITROBENZONITRILE | [CAS]
34667-88-4 | [Synonyms]
2-FLUORO-4-NITROBENZONITRILE
2-Fluoro-4-nitrobenzonitrile ,98% | [Molecular Formula]
C7H3FN2O2 | [MDL Number]
MFCD04038715 | [Molecular Weight]
166.11 | [MOL File]
34667-88-4.mol |
| Safety Data | Back Directory | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3439 | [HS Code ]
29269090 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow solid | [Synthesis]
General procedure for the synthesis of 2-fluoro-4-nitrobenzonitrile from 2-fluoro-4-nitrobenzamide: A mixture of 2-fluoro-4-nitrobenzamide (0.83 g, 4.6 mmol) and phosphorus pentoxide/hexamethyldisiloxane in 1,2-dichloroethane (20 mL) was heated and refluxed for 4 hr at 100 °C under nitrogen atmosphere. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently filtered through a silicone plug, washed first with hexane (200 mL) and then with 5% methanol/chloroform mixture (400 mL). The methanol/chloroform washings were combined and concentrated under reduced pressure to give 2-fluoro-4-nitrobenzonitrile (0.71 g, 95% yield) as a beige solid.1H NMR (DMSO-d6) data were as follows: δ 8.46 (dd, J = 9.5, 2.0 Hz, 1H), 8.37-8.22 (m, 2H). | [References]
[1] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 4, p. 1163 - 1172
[2] Patent: US6344459, 2002, B1. Location in patent: Page column 70-71
[3] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1325 - 1344
[4] Journal of Medicinal Chemistry, 2001, vol. 44, # 23, p. 3856 - 3871 |
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