| Identification | More | [Name]
3-Bromo-4-methoxybenzaldehyde | [CAS]
34841-06-0 | [Synonyms]
3-BROMO-4-METHOXYBENZALDEHYDE
3-BROMO-P-ANISALDEHYDE
AKOS B004285
AKOS BBS-00003260
ASISCHEM N43045
OTAVA-BB BB0125160184
TIMTEC-BB SBB006750
Benzaldehyde, 3-bromo-4-methoxy-
p-Anisaldehyde, 3-bromo-
3-BROMO-4-METHOXYBENZALDEHYDE 98%
3-Bromo-4-methoxybenzaldehyde, 98+% | [EINECS(EC#)]
252-241-8 | [Molecular Formula]
C8H7BrO2 | [MDL Number]
MFCD00016599 | [Molecular Weight]
215.04 | [MOL File]
34841-06-0.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO BEIGE SOLID | [Melting point ]
51-54 °C (lit.) | [Boiling point ]
108-110°C 1mm | [density ]
1.5313 (rough estimate) | [refractive index ]
1.5500 (estimate) | [Fp ]
108-110°C/1mm | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Chloroform, DMSO, Ethyl Acetate | [form ]
Solid | [color ]
Off-White | [Sensitive ]
Air Sensitive | [BRN ]
1636939 | [InChI]
InChI=1S/C8H7BrO2/c1-11-8-3-2-6(5-10)4-7(8)9/h2-5H,1H3 | [InChIKey]
QMPNFQLVIGPNEI-UHFFFAOYSA-N | [SMILES]
C(=O)C1=CC=C(OC)C(Br)=C1 | [CAS DataBase Reference]
34841-06-0(CAS DataBase Reference) | [NIST Chemistry Reference]
3-Bromo-4-methoxybenzaldehyde(34841-06-0) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT, AIR SENSITIVE | [HS Code ]
29130000 | [Storage Class]
13 - Non Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE TO BEIGE SOLID | [Uses]
3-Bromo-4-methoxybenzaldehyde may be used in the following studies:
- Asymmetric synthesis of a novel β-hydroxy-α-amino acid derivative, via Mukaiyama aldol reaction.
- Synthesis of 2-(3-bromo-4-methoxyphenyl)-5-fluorobenzothiazole.
- Preparation of 5-[(Z)-2-(3-bromo-4-methoxyphenyl)vinyl]-1,2-3-trimethoxybenzene.
- Total synthesis of engelhardione.
- Starting reagent for the synthesis of (2E)-3-(3-bromo-4-methoxyphenyl)-1-(4-methylphenyl)prop-2-en-1-one.
| [Synthesis Reference(s)]
Tetrahedron, 41, p. 2903, 1985 DOI: 10.1016/S0040-4020(01)96614-1 | [General Description]
3-Bromo-4-methoxybenzaldehyde is formed by the solvent-free bromination of 4-methoxybenzaldehyde using 1,3-di-n-butylimidazolium tribromide, as a brominating reagent. | [Synthesis]
(2) In a 4000 mL three-necked flask protected by passing nitrogen, 740.7 g of 3-bromo-4-hydroxybenzaldehyde, 2000 g of N,N-dimethylformamide and 558.0 g of potassium carbonate were added. The reaction system was cooled to 0~5 °C and 775 g of iodomethane was added dropwise slowly. After the dropwise addition, the reaction solution was concentrated and poured into ice water to precipitate a solid. After filtration and recrystallization, a white crystalline product 3-bromo-4-methoxybenzaldehyde was obtained as 752.7 g, yield 95.0%. | [References]
[1] Patent: CN107118087, 2017, A. Location in patent: Paragraph 0015; 0031; 0035; 0039; 0043; 0047 |
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