| Identification | More | [Name]
4-Bromo-3-nitrobenzotrifluoride | [CAS]
349-03-1 | [Synonyms]
1-BOMO-4-(TRIFLUOROMETHYL)-2-NITROBENZENE
3-NITRO-4-BROMOBENZOTRIFLUORIDE
3-NITRO-4-BROMOTRIFLUOROMETHYLBENZENE
4-BROMO-3-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE
4-BROMO-3-NITROBENZOTRIFLUORIDE
TIMTEC-BB SBB009903
4-Bromo-3-Nitrobenzotrifluoride 3-Nitro-4-Bromobenzotrifluoride
1-bromo-2-nitro-4-(trifluoromethyl)benzene
4-Bromo-3-nitrobenzotrifluoride 99%
4-Bromo-3-nitrobenzotrifluoride99%
4-Bromo-3-nitrobenzotrifluoride, 98+%
1-Bromo-4-(trifluoromethyl)-2-nitrobenzene | [EINECS(EC#)]
670-406-6 | [Molecular Formula]
C7H3BrF3NO2 | [MDL Number]
MFCD00014685 | [Molecular Weight]
270 | [MOL File]
349-03-1.mol |
| Chemical Properties | Back Directory | [Appearance]
clear yellow liquid | [Boiling point ]
90 °C (3 mmHg) | [density ]
1.763 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.511(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [form ]
clear liquid | [color ]
Light yellow to Amber to Dark green | [Specific Gravity]
1.763 | [BRN ]
2417762 | [CAS DataBase Reference]
349-03-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29049090 |
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow liquid | [Uses]
4-Bromo-3-nitrobenzotrifluoride may be used to prepare polysubstituted bisheterocycles with potential chemotherapeutic properties. | [General Description]
4-Bromo-3-nitrobenzotrifluoride is an organic building block. | [Synthesis]
Example 10: Synthesis of 4-bromo-3-nitrobenzotrifluoride from 4-chloro-3-nitrobenzotrifluoride (g); [0086] 4-chloro-3-nitrobenzotrifluoride (1 eq.) was synthesized from 4-chloro-3-nitrobenzotrifluoride (1 eq.) with a source of bromide (cuprous bromide, cupric bromide, lithium bromide, or magnesium bromide, 1 eq.) or a mixture of cuprous bromide (1 eq.) with lithium bromide (1 eq.) under the presence of benzyl cyanide, diethylene glycol dimethyl ether ( diethylene glycol dimethyl ether), acetic acid or N-methylpyrrolidone (1 mL/mmol) as solvent, and heated the reaction at 160 °C for 6 h to obtain the target product 4-bromo-3-nitrobenzotrifluoride. Table 11 shows that good selectivity was obtained using different reaction conditions, with the mixture of cuprous bromide and lithium bromide being particularly effective. Comparative experiments showed that the reaction was less effective under solvent-free conditions. | [References]
[1] Patent: US6635780, 2003, B1. Location in patent: Page/Page column 12
[2] Patent: US6635780, 2003, B1. Location in patent: Page/Page column 10-11
[3] Patent: US6635780, 2003, B1. Location in patent: Page/Page column 10-11
[4] Patent: US6635780, 2003, B1. Location in patent: Page/Page column 10-12
[5] Patent: US6635780, 2003, B1. Location in patent: Page/Page column 10-11 |
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