| Identification | More | [Name]
4-Fluoroacetanilide | [CAS]
351-83-7 | [Synonyms]
1-ACETAMIDO-4-FLUOROBENZENE
4'-FLUOROACETANILIDE
4-FLUOROACETANILIDE
N1-(4-FLUOROPHENYL)ACETAMIDE
N-(4-FLUOROPHENYL)ACETAMIDE
P-FLUOROACETANILIDE
4’-fluoro-acetanilid
Acetamide, N-(4-fluorophenyl)-
n-(4-fluorophenyl)-acetamid
n-p-fluorophenylacetamide
4-Fluoroacetanilide,98%
4'-Fluoroacetanilide, 99+%
4-Fluorophenyl acetamide
N-(4-Fluorophenyl)acetanilide | [EINECS(EC#)]
206-515-9 | [Molecular Formula]
C8H8FNO | [MDL Number]
MFCD00016335 | [Molecular Weight]
153.15 | [MOL File]
351-83-7.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing . | [WGK Germany ]
2
| [RTECS ]
AE2977000
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29242990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white fluffy crystalline powder | [Uses]
4-Fluoroacetanilide solutions and commercial samples serve as the crystallizing material in metastable zone width (MZW) measurements in aqueous ethanol[3]. | [Synthesis]
4-Fluoroacetanilide is prepared from commercial 4-fluoroaniline and acetic anhydride, affording a yellow solid (19%) with a melting point of 150 °C[1]. The 13C-labelled analogue, 1-[13C]-4-fluoroacetanilide, is synthesized by reacting 4-fluoroaniline directly with acetyl-1-[13C]-chloride in a 1:1.1 molar ratio, then washing with distilled water and recrystallizing from ethanol[2]. | [References]
[1]Bienvenu, A., Barthelemy, A., Boichut, S., Marquet, B., Billard, T., & Langlois, B. R. (2002). Synthesis of 4-Fluorophenols from 4-tert-Butylphenols and Fluoride Sources Under Oxidative Conditions. Collection of Czechoslovak Chemical Communications, 67(10), 1467–1478. https://doi.org/10.1135/cccc20021467
[2]SCARFE, G. B. (1999). Studies on the metabolism of 4-fluoroaniline and 4-fluoroacetanilide in rat: formation of 4-acetamidophenol (paracetamol) and its metabolites via defluorination and N-acetylation. Xenobiotica, 29(2), 205–216. https://doi.org/10.1080/004982599238759
[3]Threlfall, T. L., De'Ath, R. W., & Coles, S. J. (2013). Metastable Zone Widths, Conformational Multiplicity, and Seeding. Organic Process Research & Development, 17(3), 578–584. https://doi.org/10.1021/op3003486
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