| Identification | More | [Name]
2'-Fluoroacetanilide | [CAS]
399-31-5 | [Synonyms]
1-ACETAMIDO-2-FLUOROBENZENE
2'-FLUOROACETANILIDE
2-FLUOROACETANILIDE
2-FLUOROACETANILINE
N1-(2-FLUOROPHENYL)ACETAMIDE
N-(2-FLUOROPHENYL)ACETAMIDE
O-FLUOROACETANILIDE
2-Fluoroacetanilide, 98+%
2-Fluorophenyl acetamide
N-Acetyl 2-fluoroaniline | [EINECS(EC#)]
206-916-9 | [Molecular Formula]
C8H8FNO | [MDL Number]
MFCD00000315 | [Molecular Weight]
153.15 | [MOL File]
399-31-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29242998 |
| Hazard Information | Back Directory | [Chemical Properties]
white fine crystalline powder | [Uses]
2''-Fluoroacetanilide | [Synthesis]
Step 1: Synthesis of N-(2-fluorophenyl)acetamide
To a solution of 2-fluoroaniline (5.0 g, 45.05 mmol) in dichloromethane (DCM, 225 mL) was sequentially added acetic anhydride (4.09 mL, 45.05 mmol) and triethylamine (7.55 mL, 54.05 mmol). The reaction mixture was stirred at room temperature for 6 hours. After completion of the reaction, the mixture was concentrated, diluted with ethyl acetate and washed with 1N hydrochloric acid (2 x 50 mL). The organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated to give N-(2-fluorophenyl)acetamide (6.20 g, 90% yield) as a white solid.LCMS analysis showed the molecular ion peak of the target product to be 153.99 (M + H)+. | [References]
[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 11, p. 2187 - 2196
[2] Patent: US2008/139558, 2008, A1. Location in patent: Page/Page column 80
[3] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 7, p. 669 - 673
[4] Patent: US2012/238543, 2012, A1. Location in patent: Page/Page column 13
[5] Patent: US2012/270854, 2012, A1. Location in patent: Page/Page column 20 |
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