| Identification | Back Directory | [Name]
TQS | [CAS]
353483-92-8 | [Synonyms]
TQS
4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide
Inhibitor,modulator,acetylcholine,Nicotinic acetylcholine receptors,nAChR,allosteric,neuroinflammatory,positive,pain,inhibit,TQS,nicotinic | [Molecular Formula]
C22H20N2O2S | [MOL File]
353483-92-8.mol | [Molecular Weight]
376.47 |
| Chemical Properties | Back Directory | [Boiling point ]
609.8±65.0 °C(Predicted) | [density ]
1.311±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 50 mM in DMSO | [form ]
Powder | [pka]
10.21±0.40(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C22H20N2O2S/c23-27(25,26)15-11-12-21-20(13-15)17-8-4-10-19(17)22(24-21)18-9-3-6-14-5-1-2-7-16(14)18/h1-9,11-13,17,19,22,24H,10H2,(H2,23,25,26) | [InChIKey]
SIZWDJIHABLBSP-UHFFFAOYSA-N | [SMILES]
NS(C1=CC2=C(NC(C3=CC=CC4=C3C=CC=C4)C5C2C=CC5)C=C1)(=O)=O |
| Hazard Information | Back Directory | [Uses]
TQS is a positive allosteric modulator (Type II) of alpha7 nACh receptors, functional human α7 nicotinic acetylcholine receptor (nAChR) generated from Escherichia coli that opens a new avenue for producing mammalian Cys-loop receptors to facilitate structure-based rational drug design. | [Biological Activity]
TQS is a type-II positive allosteric modulator of α7 nAChR. TQS potentiates agonist-invoked responsesand dramatically reduces the rate of desensitization of α7 nAChR. The compound has no agonist activity alone. The EC50 for potentiation of submaximal doses of acetylcholine is 6.2μM. | [in vivo]
TQS (1 or 4 mg/kg; i.p.) reduces the expression of LPS-induced IκB mRNA, CD11b mRNA and regulates microglial morphological changes in the hippocampus[1]. | Animal Model: | Male C57BL/6J mice[1] | | Dosage: | 1 or 4 mg/kg | | Administration: | I.p. | | Result: | Reduced the expression of LPS-induced IκB mRNA, CD11b mRNA and regulated microglial morphological changes in the hippocampus.
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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