| Identification | More | [Name]
2-Methylthiazole | [CAS]
3581-87-1 | [Synonyms]
2-METHYL-1,3-THIAZOLE
AURORA KA-6469
Thiazole, 2-methyl-
thiazole,2-methyl-
2-METHYLTHIAZOLE 98+% | [EINECS(EC#)]
222-702-8 | [Molecular Formula]
C4H5NS | [MDL Number]
MFCD00053144 | [Molecular Weight]
99.15 | [MOL File]
3581-87-1.mol |
| Questions And Answer | Back Directory | [Preparation]
2-Bromothiazole (5.0 g, 30.5 mmol) was added stepwise to n-BuLi (14.6 mL of 1.6 M hexane, 36.6 mmol) in Et₂O (60 mL) at -78°C under nitrogen. The reaction mixture was stirred for 40 minutes, then dimethyl sulfate (4.75 mL, 50.3 mmol) was added dropwise, and the reaction mixture was heated to -10°C (and placed in a refrigerator) and allowed to stand overnight. The reaction mixture was heated to 0°C and carefully quenched with 2 M HCl (40 mL). The organic layer was separated and extracted with 2 M HCl (2×). The acidic extract was combined with 2 M NaOH to form a strongly basic solution and extracted with Et₂O (4×). The combined organic extract was dried over KOH, the solvent was distilled at atmospheric pressure, and then 2-methylthiazole was distilled off at 128–130°C. |
| Chemical Properties | Back Directory | [Melting point ]
-24 °C | [Boiling point ]
129 °C | [density ]
1.11 | [refractive index ]
1.5190-1.5230 | [Fp ]
29 °C | [storage temp. ]
Sealed in dry,Room Temperature | [Water Solubility ]
Completely miscible in water | [form ]
liquid | [pka]
pK1:3.40(+1) (25°C,μ=0.1) | [color ]
Colorless to Yellow | [Odor]
at 0.10 % in propylene glycol. green vegetable | [Odor Type]
green | [InChI]
1S/C4H5NS/c1-4-5-2-3-6-4/h2-3H,1H3 | [InChIKey]
VZWOXDYRBDIHMA-UHFFFAOYSA-N | [SMILES]
Cc1nccs1 | [LogP]
0.343 (est) | [CAS DataBase Reference]
3581-87-1(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Methylthiazole(3581-87-1) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS02 | [Signal word ]
Warning | [Hazard statements ]
H226 | [Precautionary statements ]
P210-P233-P240-P241+P242+P243-P280-P303+P361+P353-P403+P235-P501 | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
1993 | [WGK Germany ]
WGK 3 | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
2934100090 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Flam. Liq. 3 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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Energy Chemical
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400-0056266 |
| Website: |
www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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jiliang chemicals
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21-62165282 |
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http://www.jiliangchem.com |
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