| Identification | More | [Name]
L(-)-Camphorsulfonic acid | [CAS]
35963-20-3 | [Synonyms]
(-)-10-CAMPHORSULFONIC ACID
(1R)-(-)-10-CAMPHORSULFONIC ACID
(1r)-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulphonic acid
(1R)-(-)-CAMPHOR-10-SULFONIC ACID
(1R)-CAMPHOR-10-SULFONIC ACID
(1R)-(-)-CAMPHOR-10-SULPHONIC ACID
(1R)-(-)-CAMPHORSULFONIC ACID
(-)-CAMPHOR-10-SULFONIC ACID
(-)-CAMPHOR-10-SULPHONIC ACID
L-10-(-)-CAMPHOR SULFONIC ACID
L-(-)-CAMPHOR-10-SULFONIC ACID
L-(-)-CAMPHORSULFONIC ACID
L-(+)-CAMPHOR SULFONIC ACID
L(+)-CAMPHORSULPHONIC ACID
L-CAMPHORSULPHONIC ACID
2-Oxo-10-bornane-sulfonicacid
7,7-Dimethyl-2-oxobicyclo[2,2,1]heptane-1-methane-sulfonicacid
Camphor-sulphonicacid
(1R)-(−
)-10-Camphorsulfonic acid
d-Camphor-10-sulphonic acid | [EINECS(EC#)]
252-817-9 | [Molecular Formula]
C10H16O4S | [MDL Number]
MFCD00064158 | [Molecular Weight]
232.3 | [MOL File]
35963-20-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
198 °C (dec.)(lit.)
| [alpha ]
-22 º (c=20,H2O) | [Boiling point ]
344.46°C (rough estimate) | [density ]
1.2981 (rough estimate) | [refractive index ]
-21.5 ° (C=5, H2O) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Sparingly) | [form ]
Crystalline Powder | [pka]
1.17±0.50(Predicted) | [color ]
White to slightly beige | [PH]
1.2-1.4 (20g/l, H2O) | [Stability:]
Stable. Hygroscopic. Incompatible with strong bases, strong oxidizing agents. | [Optical Rotation]
[α]20/D 21°, c = 2 in H2O | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [BRN ]
2809676 | [InChI]
1S/C10H16O4S/c1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h7H,3-6H2,1-2H3,(H,12,13,14)/t7-,10-/m0/s1 | [InChIKey]
MIOPJNTWMNEORI-XVKPBYJWSA-N | [SMILES]
[H][C@]12CC[C@](CS(O)(=O)=O)(C(=O)C1)C2(C)C | [CAS DataBase Reference]
35963-20-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S24/25:Avoid contact with skin and eyes .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [F ]
3-10 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29147090 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Eye Dam. 1
Skin Corr. 1B |
| Questions And Answer | Back Directory | [L-Camphorsulfonic acid]
Camphor sulfonic acid includes L-camphor sulfonic acid, D-camphor sulfonic acid and racemic camphor sulfonic acid these three isomers.
It is a kind of white columnar crystals with the melting point of 193°C (decomposition). [α]D20+24° (water). It is Slightly soluble in ethanol, insoluble in ether, soluble in sodium hydroxide and sodium carbonate solution. L-camphor sulfonic acid could be produced from reaction between camphor, sulfuric acid and acetic anhydride.It has a lot of functions such as exciting the respiratory center, the vascular movement center and myocardium. Its sodium salt plays pharmaceutical role in medicine.
Camphor sulfonic acid sodium salt is a kind of white crystalline powder. It is odorless and tastes bitter and then sweet. It is easily absorb moisture and easily dissolve in the water and hot ethanol. So it should be shading confined preservation. it can Directly excite the medulla oblongata respiratory center and vascular movement center, and quicken and deepen the breath, rise the blood pressure; it also can directly excite the myocardium and strength the contraction of cardiac muscle as well as could increase the output.
It is applied the treatment of infectious disease, as well as the disease like central inhibition of poisoning caused by respiratory depression, fatigue, high fever, poisoning, heat stroke and other acute heart failure. | [Uses]
(1) It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent. | [Production method]
Camphor sulfonic acid is obtained from camphor and sulfuric acid by irradiation.
This method involves:
1) Adding the camphor and acetic anhydride to the pot.
2) Mixing it and making it dissolved.
3) Dripping sulfuric acid after cooling. And the reaction should be maintained at 44-45 °C for 48 hours. Then cool it to 6-7 °C.
4) Crystallizing, filtrating, washing with a small amount of acetic acid crystals, and dry it to get camphor sulfonic acid. |
| Hazard Information | Back Directory | [Physical properties]
(1R)-(-)-10-Camphorsulfonic acid is a kind of prismatic crystals and its melting point is 193-195 ° C (decompose). It is Insoluble in ether and slightly soluble in glacial acetic acid and ethyl acetate. And it is and moisture in wet air. | [Definition]
ChEBI: The R enantiomer of camphorsulfonic acid. | [General Description]
(1R)-(-)-10-Camphorsulfonic acid is an HPLC derivatization reagent for UV/Vis detection. It is mainly employed for the resolution of bases. | [Synthesis]
Induced crystallization resolution of racemic camphorsulfonate to obtain enantiomers:
1. Formation of a racemic salt (e.g., ammonium salt).
2. To solutions of the racemic salt, a dextro- or levo- optically active inducer is added to induce crystalli | [Purification Methods]
It forms prisms from AcOH or EtOAc, and is deliquescent in moist air. Store it in tightly stoppered bottles. The NH4 salt forms needles from H2O [] D ±20.5o (c 5, H2O). [Burgess & Lowry J Chem Soc 127 279 1925, Marsi et al. J Am Chem Soc [ 78 3063 1956.] The RS-acid recrystallises from AcOH. [60g of (±)-acid in 60mL of AcOH at 105o gave 40g of crystals has m 202-203o [Bartlett & Knox Org Synth 45 12 1965.] [Beilstein 11 IV 642.] |
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Energy Chemical
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