| Identification | More | [Name]
2',3'-O-Isopropylideneguanosine | [CAS]
362-76-5 | [Synonyms]
2',3'-IPG
2',3'-ISOPROPYLIDENE-GUANOSINE
2',3'-O-ISOPROPYLIDENE-GUANOSINE
2',3'-O-Isopropylidene-D-guanosine
9-(2,3-O-Isopropylidene-beta-D-ribofuranosyl)guanine | [EINECS(EC#)]
206-651-9 | [Molecular Formula]
C13H17N5O5 | [MDL Number]
MFCD00057081 | [Molecular Weight]
323.3 | [MOL File]
362-76-5.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
296 °C | [density ]
1.93±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO, 15% Ammonium Hydroxide, Hot 50% aq. Ethanol, Methanol, Warm Water | [form ]
Solid | [pka]
9?+-.0.20(Predicted) | [color ]
White to Off-White | [biological source]
synthetic (organic) | [Usage]
A useful precursor for the preparation of nucleic acids | [InChI]
InChI=1S/C13H17N5O5/c1-13(2)22-7-5(3-19)21-11(8(7)23-13)18-4-15-6-9(18)16-12(14)17-10(6)20/h4-5,7-8,11,19H,3H2,1-2H3,(H3,14,16,17,20)/t5-,7-,8-,11-/m1/s1 | [InChIKey]
XKPDAYWPKILAMO-IOSLPCCCSA-N | [SMILES]
OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@@H]2OC(O[C@H]12)(C)C | [CAS DataBase Reference]
362-76-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | [Safety Statements ]
24/25 | [WGK Germany ]
3
| [HS Code ]
29349990 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
2',3'-O-Isopropylideneguanosine is a useful precursor for the preparation of nucleic acids
| [Uses]
A useful precursor for the preparation of nucleic acids. | [Synthesis]
Add 10 mL of anhydrous pyridine to 2 g (7.45 mmol) of solid 2',3'-O-Isopropylideneguanosine to form a white suspension.
1 Remove the pyridine under reduced pressure to remove any trapped water;
2 Repeat the previous step;
3 Add 5 mL of acetone to the residue and stir for 30 minutes;
4 Add 50 mL of ether to the mixture and stir for 1 hour;
5 Filter the resulting precipitate and wash it with ether;
6 Dry the product in a vacuum desiccator over P2O5.
| [References]
[1] RSC Advances, 2018, vol. 8, # 57, p. 32775 - 32793
[2] Synlett, 2010, # 19, p. 2959 - 2963
[3] Patent: WO2006/130161, 2006, A2. Location in patent: Page/Page column 29
[4] Chemistry - A European Journal, 2013, vol. 19, # 35, p. 11502 - 11506
[5] Chemistry - A European Journal, 2014, vol. 20, # 11, p. 3023 - 3028 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Credit-Chem Co., Ltd.
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