| Identification | More | [Name]
2-Fluoropyridine | [CAS]
372-48-5 | [Synonyms]
2-FLUOROPYRIDINE
2-fluoro-pyridin
Pyridine, 2-fluoro-
2-Fluoropyride
2-Fluoroypyridine
2-Fluoropyridine,99%
2-CYANOPHENYLBORONIC ACID | [EINECS(EC#)]
206-757-5 | [Molecular Formula]
C5H4FN | [MDL Number]
MFCD00006224 | [Molecular Weight]
97.09 | [MOL File]
372-48-5.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLOURLESS TO LIGHT YELLOW LIQUID | [Boiling point ]
126 °C/753 mmHg (lit.) | [density ]
1.128 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.466(lit.)
| [Fp ]
83 °F
| [storage temp. ]
Flammables area | [form ]
Liquid | [pka]
-0.44(at 25℃) | [color ]
Clear colorless to light yellow | [Specific Gravity]
1.13 | [Water Solubility ]
Soluble in water. | [BRN ]
1515 | [Dielectric constant]
37.289999999999999 | [InChI]
InChI=1S/C5H4FN/c6-5-3-1-2-4-7-5/h1-4H | [InChIKey]
MTAODLNXWYIKSO-UHFFFAOYSA-N | [SMILES]
C1(F)=NC=CC=C1 | [CAS DataBase Reference]
372-48-5(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Fluoropyridine(372-48-5) |
| Questions And Answer | Back Directory | [Synthesis]
A rare example of fluorodenitration of a heterocyclic system was provided by 2-
nitropyridine, which was converted to 2-fluoropyridine.
 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,F,Xn | [Risk Statements ]
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [RTECS ]
UT3900000
| [Hazard Note ]
Flammable/Irritant | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29333999 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
2(5H)-Pyridinone(9CI)-->2-PYRIDYL TRIFLUOROMETHANESULFONATE-->Perfluoro-2-methyl-2-pentene-->2,4,6-TRIFLUOROPYRIDINE-->2,4-DIFLUORO-PYRIDINE-->2-Nitropyridine | [Preparation Products]
2-(5-BROMO-2-THIENYL)PYRIDINE-->2-Fluoro-3-pyridylboronic acid-->2,6-Difluoropyridine-->Pyrrolidine, 2,2,3,3,4,4,5,5-octafluoro-1-(trifluoromethyl)--->2-Pyridylacetonitrile-->3-Bromo-2-fluoropyridine-->2-Fluoro-3-iodopyridine-->2-Fluoro-3,6-diiodopyridine |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLOURLESS TO LIGHT YELLOW LIQUID | [Uses]
2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines. |
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