| Identification | More | [Name]
2,2-Difluoropropionic acid | [CAS]
373-96-6 | [Synonyms]
2,2-DIFLUOROPROPIONIC ACID | [Molecular Formula]
C3H4F2O2 | [MDL Number]
MFCD03093764 | [Molecular Weight]
110.06 | [MOL File]
373-96-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
38-45 °C | [Boiling point ]
25-30 °C/5 mmHg | [density ]
1.316±0.06 g/cm3(Predicted) | [Fp ]
25-30°C/5mm | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [pka]
1.34±0.10(Predicted) | [color ]
White to Almost white | [InChI]
InChI=1S/C3H4F2O2/c1-3(4,5)2(6)7/h1H3,(H,6,7) | [InChIKey]
PMWGIVRHUIAIII-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C(F)(F)C | [CAS DataBase Reference]
373-96-6(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
2,2-Difluoropropionic acid is a useful research chemical. | [Application]
2,2-Difluoropropionic acid is mainly used in biochemical research. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,C | [Risk Statements ]
R34:Causes burns.
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3261 | [WGK Germany ]
3 | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29159000 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Synthesis]
The general procedure for synthesizing 2,2-difluoropropionic acid from ethyl 2,2-difluoropropionate was as follows: referring to Example G38, ethyl 2,2-difluoropropionate (1.2 g, 8.8 mmol) was dissolved in ethanol (26 mL), followed by the slow addition of 2N aqueous sodium hydroxide solution (26 mL). The reaction mixture was stirred at 0 °C, then gradually warmed to room temperature and continued stirring for 14 hours. Upon completion of the reaction, the reaction mixture was acidified to pH < 7 with 2N hydrochloric acid and then extracted with ether. The organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 2,2-difluoropropionic acid (0.90 g, 92% yield). The product was an oil with the following 1H-NMR (CDCl3) data: δ 1.85 (3H, t, J = 19.0 Hz), 6.21 (1H, br s). | [References]
[1] Patent: EP1402900, 2004, A1
[2] Patent: US2004/53973, 2004, A1
[3] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, p. 1260 - 1263
[4] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 7, p. 1417 - 1420
[5] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 1597 - 1601 |
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