| Identification | More | [Name]
6-Fluoro-2-methylindanone | [CAS]
37794-19-7 | [Synonyms]
6-FLUORO-2-METHYL-1-INDANONE
6-FLUORO-2-METHYLINDANONE
2-Methyl-6-fluoro-1-indanone
6-FLUORO-2-METHYL-2,3-DIHYDRO-1H-INDEN-1-ONE
2-METYL-6-FLUORO-1-INDANONE | [EINECS(EC#)]
609-478-0 | [Molecular Formula]
C10H9FO | [MDL Number]
MFCD00029129 | [Molecular Weight]
164.18 | [MOL File]
37794-19-7.mol |
| Chemical Properties | Back Directory | [Boiling point ]
240.9±29.0 °C(Predicted) | [density ]
1.179±0.06 g/cm3(Predicted) | [vapor pressure ]
3.07Pa at 25℃ | [storage temp. ]
Sealed in dry,Room Temperature | [Water Solubility ]
307.4mg/L at 25℃ | [Detection Methods]
HPLC,NMR | [InChI]
InChI=1S/C10H9FO/c1-6-4-7-2-3-8(11)5-9(7)10(6)12/h2-3,5-6H,4H2,1H3 | [InChIKey]
BABIQLUCYVRCIX-UHFFFAOYSA-N | [SMILES]
C1(=O)C2=C(C=CC(F)=C2)CC1C | [LogP]
2.73 | [CAS DataBase Reference]
37794-19-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
6-Fluoro-2-methylindan-1-one is a key intermediate in the synthesis of sulindac. This compound is converted to sulindac via hydrolysis following condensation with cyanoacetic acid, followed by condensation with p-methylthiobenzaldehyde and subsequent oxidation. Sulindac is a non-steroidal prodrug with minimal biological activity; once it enters the body, it is metabolised into an active sulphide compound. This compound inhibits cyclooxygenase and reduces the synthesis of prostaglandins, thereby exerting analgesic, anti-inflammatory and antipyretic effects. It is primarily used to treat pain, rheumatoid arthritis, ankylosing spondylitis and gouty arthritis. | [Hazard]
6-fluoro-2-methylindan-1-one is irritating to humans. Contact may cause skin irritation and severe eye irritation, and may also cause respiratory tract irritation. Therefore, wear a protective face mask when using this substance. |
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