| Identification | More | [Name]
2-Chloro-6-fluorobenzaldehyde | [CAS]
387-45-1 | [Synonyms]
2-CHLORO-6-FLUOROBENZALDEHYDE
2-FLUORO-6-CHLORO BENZALDEHYDE
AKOS BBS-00003159
LABOTEST-BB LT00942032
OTAVA-BB BB7018801953
2-chloro-6-fluoro-benzaldehyd
2-Choro-6-Fluoro Benzaldehyde
2-Chloro-6-fluorobenzaldehyde,min.96%
2-CHLORO-6-FLUOROBENZALDEHYDE,99%
2-Chloro-6-fluorobenzaldehyde97%
2-Chlor-6-fluorbenzaldehyd
4-Chloro-6-fluorobenzaldehyde
Benzaldehyde, 2-chloro-6-fluoro-
2-Chloro-6-fluorobenzaldehyde, min. 96% | [EINECS(EC#)]
206-860-5 | [Molecular Formula]
C7H4ClFO | [MDL Number]
MFCD00003306 | [Molecular Weight]
158.56 | [MOL File]
387-45-1.mol |
| Chemical Properties | Back Directory | [Appearance]
whitetoyellowcrystallinesoli | [Melting point ]
32-35 °C(lit.)
| [Boiling point ]
92 °C (10 mmHg)
| [density ]
1.3310 (estimate) | [Fp ]
215 °F
| [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Crystalline Solid | [color ]
White to yellow | [Water Solubility ]
Insoluble | [Sensitive ]
Air Sensitive | [BRN ]
2245530 | [InChI]
InChI=1S/C7H4ClFO/c8-6-2-1-3-7(9)5(6)4-10/h1-4H | [InChIKey]
OACPOWYLLGHGCR-UHFFFAOYSA-N | [SMILES]
C(=O)C1=C(F)C=CC=C1Cl | [CAS DataBase Reference]
387-45-1(CAS DataBase Reference) | [EPA Substance Registry System]
387-45-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
1
| [Hazard Note ]
Irritant | [TSCA ]
T | [HazardClass ]
IRRITANT | [HS Code ]
29130000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
whitetoyellowcrystallinesoli | [Uses]
2-Chloro-6-fluorobenzaldehyde was used in the synthesis of novel copolymers of methyl 2-cyano-3-dihalophenyl-2-propenoates and styrene. | [General Description]
2-Chloro-6-fluorobenzaldehyde undergoes piperidine catalyzed Knoevenagel condensation reaction with methyl cyanoacetate to yield methyl 2-cyano-3-dihalophenyl-2-propenoate. | [Synthesis]
GENERAL METHOD: A mixture of 2-chloro-6-fluorobenzyl alcohol (1.0 mmol), N-phenylglycine (0.0076 g, 0.05 mmol), CuBr2 (0.0112 g, 0.05 mmol), Na2CO3 (0.1060 g, 1.0 mmol), and TEMPO (0.0078 g, 0.05 mmol) was added to a 100 mL Schlenk tube with H2O (3.0 mL) was added to a 100 mL Schlenk tube. It was stirred vigorously for 0.5 h under reflux conditions in air. After completion of the reaction, the product was extracted with CH2Cl2 (3 x 2.0 mL). The organic phases were combined, washed with H2O (3.0 mL) and dried with anhydrous MgSO4. After vacuum concentration, the residue was purified by column chromatography to give 2-chloro-6-fluorobenzaldehyde. Isolated yield: 0.1080 g (90%). | [References]
[1] Synthetic Communications, 2008, vol. 38, # 15, p. 2638 - 2645
[2] Journal of the American Chemical Society, 2011, vol. 133, # 42, p. 16901 - 16910
[3] RSC Advances, 2014, vol. 4, # 90, p. 48777 - 48782
[4] Journal of Organic Chemistry, 2015, vol. 80, # 21, p. 11184 - 11188
[5] Synlett, 2015, vol. 26, # 6, p. 779 - 784 |
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