| Identification | More | [Name]
Lithium triisobutylhydroborate | [CAS]
38721-52-7 | [Synonyms]
LITHIUM TRIISOBUTYLHYDROBORATE
LITHIUM TRI-S-BUTYLHYDROBORATE
LITHIUM TRI-SEC-BUTYLBOROHYDRIDE
LITHIUM TRI-SEC-BUTYLHYDRIDOBORATE
L-SELECTRIDE(R)
lithium,(beta-4)-borate(1-hydrotris(1-methylpropyl)-
lithiumtri-sec-butylborohydride,calselect?li,
lithiumtri-sec-butylborohydride,calselect?li,intetrahydrofuran
lithium tri-sec-butylhydroborate
Lithiumbutylborohydride
L-selectride
Lithium tri-sec-butylborohydride, in tetrahydrofuran, 1M solution
LITHIUM TRI-SEC-BUTYLBOROHYDRIDE SOL.
LITHIUM TRI-SEC-BUTYLBOROHYDRIDE SOL., 1 M IN THF A 800 ML
L-SELECTRIDE, 1.0M SOLUTION IN TETRAHYDR OFURAN
1.0MinTHF
1.0MsolutioninTHF
Lithium tri-sec-butylborohydride, 1M solution in THF
Borate(1-), hydrotris(1-methylpropyl)-, lithium, (T-4)-
lithium tri-sec-butylborohydride solution | [EINECS(EC#)]
254-101-1 | [Molecular Formula]
C12H28BLi | [MDL Number]
MFCD00011708 | [Molecular Weight]
190.1 | [MOL File]
38721-52-7.mol |
| Questions And Answer | Back Directory | [Description]
Lithium tri-sec-butylborohydride, commercially available as a one molar solution in tetrahydrofuran. It is widely used as a mild and strong reducing agent with high stereoselectivity in organic synthesis. | [Features]
Lithium tri-sec-butylborohydride is a new type of hydride reducing agent, which has the characteristics of strong reducing ability and high regio- and stereoselectivity. | [Preparation]
Lithium triisobutylhydroborate can be prepared by:In a 3000ml three-necked flask, add 1000ml of 1mol/L tri-sec-butylboron tetrahydrofuran solution, add 1000ml of 1mol/L triethylenediamine tetrahydrofuran solution simultaneously, introduce nitrogen to start stirring, put the mixture of the two in an ice-water bath After cooling to 0° C., 1000 ml of a 1 mol/L lithium aluminum hydride solution in tetrahydrofuran was slowly added dropwise to the above mixed solution with a constant pressure funnel for about 10 hours. |
| Safety Data | Back Directory | [Symbol(GHS) ]
   
GHS02,GHS05,GHS07,GHS08 | [Signal word ]
Danger | [Hazard statements ]
H318-H225-H250-H260-H314-H335-H351 | [Precautionary statements ]
P310-P370+P378i-P402+P404-P210-P231+P232-P280-P305+P351+P338-P370+P378-P422 | [Hazard Codes ]
F,C | [Risk Statements ]
R11:Highly Flammable.
R14/15:Reacts violently with water, liberating extremely flammable gases .
R17:Spontaneously flammable in air.
R34:Causes burns.
R35:Causes severe burns.
R19:May form explosive peroxides. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S7/8:Keep container tightly closed and dry .
S30:Never add water to this product . | [RIDADR ]
UN 3394 4.2/PG 1
| [WGK Germany ]
1
| [F ]
10 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
4.3 | [PackingGroup ]
II | [HS Code ]
29319090 |
| Hazard Information | Back Directory | [Physical properties]
clear colourless solution | [Uses]
Lithium triisobutylhydroborate is used as a reducing agent. Reagent for: Enantioselective synthesis of a-amino acids via reduction of N-tert-butanesulfinyl ketimine esters. Diastereoselective reduction reactions. Hydride reduction of the Danishefsky pyranones. Asymmetric reductive aldol reaction of enones with a-alkoxy aldehydes. Synthesis of alkanols by carbonylation reactions. | [Uses]
L-Selectride Solution is a reducing agent which is used in the preparation of oxygen heterocycles. Used also as a reactant in the synthesis of novel bicicyclo[3.1.0]hexane analags which may prove useful in the treatment of depression. | [Production Methods]
L-Selectride can be readily prepared by addition of tri-sec-butylborane to a tetrahydrofuran solution of lithium aluminium hydride at room temperature. It is obtained as colorless solution in tetrahydrofuran[1].
 | [References]
[1] H.J.-Wang. (2009). Lithium tri-sec-Butylborohydride (l-Selectride): A Powerful and Highly StereoselectiveReducing Reagent. Synlett, 34 1, 2037–2038. https://doi.org/10.1055/S-0029-1217551
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