| Identification | More | [Name]
7-(Trifluoromethyl)indoline-2,3-dione | [CAS]
391-12-8 | [Synonyms]
7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE
7-(TRIFLUOROMETHYL)INDOLINE-2,3-DIONE
7-(TRIFLUOROMETHYL)ISATIN
BUTTPARK 24\07-40
7-(trifluoromethyl)indole-2,3-dione
7-(Trifluoromethyl)indoline-2,3-dione 98%
7-(Trifluoromethyl)indoline-2,3-dione98%
7-TRIFLUOROMETHYLINDOLE | [EINECS(EC#)]
672-653-5 | [Molecular Formula]
C9H4F3NO2 | [MDL Number]
MFCD01248408 | [Molecular Weight]
215.13 | [MOL File]
391-12-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Brown Solid | [Melting point ]
192-193 | [density ]
1.525±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.43±0.20(Predicted) | [color ]
Very Dark Yellow to Brown | [Usage]
An indole derivative as inhibitor of COX-1, COX-2, and ?catenin.Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer disease. | [InChI]
InChI=1S/C9H4F3NO2/c10-9(11,12)5-3-1-2-4-6(5)13-8(15)7(4)14/h1-3H,(H,13,14,15) | [InChIKey]
MXLDJTXXAYVWDF-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC=C2C(F)(F)F)C(=O)C1=O | [CAS DataBase Reference]
391-12-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
7-(Trifluoromethyl)indoline-2,3-dione is Brown Solid
| [Uses]
7-(Trifluoromethyl)indoline-2,3-dione is an indole derivative as inhibitor of COX-1, COX-2, and ?catenin.Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer disease.
| [Uses]
An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer's disease. | [Uses]
An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer''s disease. | [Synthesis]
General procedure: Concentrated sulfuric acid (95 mL) was preheated in a thermostatic flask at 60 °C. Intermediate 2 ((2E)-2-(hydroxyimino)-N-[2-(trifluoromethyl)phenyl]acetamide, 12 g, 52 mmol) was added slowly in batches while keeping the reaction temperature below 70 °C. Subsequently, the temperature of the reaction system was raised to 80°C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by slow pouring into crushed ice under vigorous stirring. The precipitated solid precipitate was collected by filtration and dried in a vacuum drying oven to give the final product 3 (7-(trifluoromethyl)dihydroindole-2,3-dione). | [References]
[1] Chinese Chemical Letters, 2017, vol. 28, # 6, p. 1248 - 1251
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 1, p. 22 - 26
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 16, p. 6003 - 6017 |
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J & K SCIENTIFIC LTD.
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Energy Chemical
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Tetranov Biopharm
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China Langchem Inc.
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