Back to ChemicalBook Home--->CAS DataBase List--->39236-46-9

39236-46-9

39236-46-9 Structure

39236-46-9 Structure
IdentificationMore
[Name]

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea
[CAS]

39236-46-9
[Synonyms]

1,1-METHYLENEBIS[3-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
IMIDAZOLIDINYL UREA
IMIDUREA
LABOTEST-BB LT00772046
n,n-methylenebis n'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea
N,N''-METHYLENEBIS[N'-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
N,N''-METHYLENEBIS[N-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
germall115
methanebis(n,n’-(5-ureido-2,4-diketotetrahydroimidazole)-n,n-dimethylol)
n,n’’-methylenebis(n’-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-ure
n,n’’-methylenebis[n’-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-ure
Biopure 100
Imidurea NF
Sept 115
Tristat 1U
Unicide U-13
N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea]
N.N''-Methylenebis-{N'-(3-hydroxymethyl)-2,5-dioxo-4-imidazolenyl-urea}
Imidurea, 26-28% nitrogen
Urea, N,N-methylenebisN-3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl-
[EINECS(EC#)]

254-372-6
[Molecular Formula]

C11H16N8O8
[MDL Number]

MFCD00221482
[Molecular Weight]

388.29
[MOL File]

39236-46-9.mol
Chemical PropertiesBack Directory
[Appearance]

solid with a mild odour
[Melting point ]

141-143℃
[Boiling point ]

514.04°C (rough estimate)
[density ]

1.4245 (rough estimate)
[refractive index ]

1.6910 (estimate)
[storage temp. ]

2-8°C
[solubility ]

Soluble in water and in glycerol, but insoluble in almost all organic solvents.
[form ]

Liquid
[pka]

7.41±0.10(Predicted)
[color ]

Clear
[Stability:]

Stable.
[Water Solubility ]

soluble
[Merck ]

14,4916
[InChIKey]

ZCTXEAQXZGPWFG-UHFFFAOYSA-N
[Contact allergens]

Imidazolidinyl urea, a formaldehyde releaser related to diazolidinyl urea (see above), is used as an antimicrobial agent very active against Gram-positive and Gram-negative bacteria, used as a synergist in combination with para- bens. It is used as a preservative in aqueous products, mainly in cosmetics, toiletries, and liquid soaps.
[Uses]

imidazolidinyl urea is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential. In 2010, it was the tenth most frequently used preservative in the united States (parabens ranged from first to sixth place). generally, imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity. Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions, there is no detection of free formaldehyde release. of all the formaldehydereleasing preservatives, imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.
[CAS DataBase Reference]

39236-46-9(CAS DataBase Reference)
[EPA Substance Registry System]

39236-46-9(EPA Substance)
Hazard InformationBack Directory
[Chemical Properties]

solid with a mild odour
[Uses]

Antimicrobial
[Uses]

Antimicrobial preservative in cosmetics and topical pharmaceutical preparations.
[Description]

Imidazolidinyl urea, a formaldehyde releaser, is mainly contained in cosmetics and liquid soaps.
[Production Methods]

Imidurea is produced by the condensation of allantoin with formaldehyde.
[Pharmaceutical Applications]

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is a broad-spectrum antimicrobial preservative used in cosmetics and topical pharmaceutical formulations; typical concentrations used are 0.03–0.5% w/w. It is effective between pH 3–9 and is reported to have synergistic effects when used with parabens.
[Safety]

Imidurea is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. However, there have been some reports of contact dermatitis associated with imidurea, although these are relatively few considering its widespread use in cosmetics. Although imidurea releases formaldehyde, it does not appear to be associated with cross-sensitization with formaldehyde or other formaldehyde-releasing compounds.
LD50 (mouse, oral): 7.2 g/kg
LD50 (rabbit, skin): > 8 g/kg
LD50 (rat, oral): 11.3 g/kg
[storage]

Imidurea is hygroscopic and should be stored in a well-closed container in a cool, dry place.
[Incompatibilities]

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is incompatible with strong oxidants. It is compatible with other preservatives including sorbic acid and quaternary ammonium compounds. It is also compatible with other pharmaceutical and cosmetic excipients including proteins, nonionic surfactants, and lecithin.
[Regulatory Status]

Included in the FDA Inactive Ingredients Database (topical preparations). Accepted for use in cosmetics in Europe and the USA. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36:Irritating to the eyes.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

2
[RTECS ]

YT7365000
[TSCA ]

Yes
[HS Code ]

29332990
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea(39236-46-9).msds
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Imidurea, 26-28% nitrogen(39236-46-9)
[Sigma Aldrich]

39236-46-9(sigmaaldrich)
39236-46-9 suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Fax:
Website: https://www.dakenchem.com/
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Fax: 0371-55170693
Website: www.tianfuchem.net
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418679
Fax: 86-0551-65418697
Website: www.tnjchem.com
Company Name: Tianjin Zhongxin Chemtech Co., Ltd.
Tel: 022-66880623
Fax: 022-66880086
Website: www.tjzxchem.com
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList30845/0.htm
Company Name: career henan chemical co
Tel: +86-371-86658258
Fax:
Website: www.coreychem.com/index.html
Company Name: Jinan Finer Chemical Co., Ltd
Tel: +86-531-88989536 , +8615508631887
Fax: +86-531-88989539
Website: www.finerchem.com
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +8619930503282
Fax:
Website: https://www.chemicalbook.com/manufacturer/crovell/
Company Name: Shandong chuangyingchemical Co., Ltd.
Tel: 18853181302
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList103425/0.htm
Company Name: BOC Sciences
Tel: 1-631-485-4226
Fax: 1-631-614-7828
Website: https://www.chemicalbook.com/ShowSupplierProductsList518419/0.htm
Company Name: Shanghai Longyu Biotechnology Co., Ltd.
Tel: +8615821988213
Fax: +86 15821988213
Website: https://www.chemicalbook.com/manufacturer/ExhibitionBooth164/
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
Fax:
Website: http://www.chemdad.com/
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: 86-18523575427
Fax:
Website: https://www.canbipharm.com/
Company Name: Zhuozhou Wenxi import and Export Co., Ltd
Tel: +8613111626072 (WhatsApp)
Fax: Wechat: +8613111626072 Wickr me: waynehu
Website: www.wenxichem-pharma.com
Company Name: SIMAGCHEM CORP
Tel: +86 13806087780 , 13806087780
Fax:
Website: www.simagchem.com
Company Name: Target Molecule Corp
Tel: 781-999-5354 , 18019718960
Fax:
Website: https://www.targetmol.com/
Company Name: Hebei Ruiyao Biotechnology Co. Ltd
Tel: 15632182983 , 15532235888
Fax: 031188180881
Website: www.chemicalbook.com/manufacturer/ExhibitionBooth373
Company Name: Connect Chemicals GmbH
Tel: +49 2102 2077-39
Fax: +49 2102 2077-40
Website: connectchemicals.com/en
Tags:39236-46-9 Related Product Information
158355-41-0 32289-58-0 1271-55-2 64-10-8 90-11-9 366-18-7 98-73-7 57-13-6 97-59-6 78491-02-8 616-04-6 39236-46-9 120-93-4