| Identification | More | [Name]
N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea | [CAS]
39236-46-9 | [Synonyms]
1,1-METHYLENEBIS[3-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
IMIDAZOLIDINYL UREA
IMIDUREA
LABOTEST-BB LT00772046
n,n-methylenebis n'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea
N,N''-METHYLENEBIS[N'-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
N,N''-METHYLENEBIS[N-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
germall115
methanebis(n,n’-(5-ureido-2,4-diketotetrahydroimidazole)-n,n-dimethylol)
n,n’’-methylenebis(n’-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-ure
n,n’’-methylenebis[n’-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-ure
Biopure 100
Imidurea NF
Sept 115
Tristat 1U
Unicide U-13
N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea]
N.N''-Methylenebis-{N'-(3-hydroxymethyl)-2,5-dioxo-4-imidazolenyl-urea}
Imidurea, 26-28% nitrogen
Urea, N,N-methylenebisN-3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl- | [EINECS(EC#)]
254-372-6 | [Molecular Formula]
C11H16N8O8 | [MDL Number]
MFCD00221482 | [Molecular Weight]
388.29 | [MOL File]
39236-46-9.mol |
| Chemical Properties | Back Directory | [Appearance]
solid with a mild odour | [Melting point ]
141-143℃ | [Boiling point ]
514.04°C (rough estimate) | [density ]
1.4245 (rough estimate) | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.6910 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in water and in glycerol, but insoluble in almost
all organic solvents. | [form ]
Liquid | [pka]
7.41±0.10(Predicted) | [color ]
Clear | [Stability:]
Stable. | [Water Solubility ]
soluble | [Merck ]
14,4916 | [Major Application]
pharmaceutical (small molecule) | [Cosmetics Ingredients Functions]
PRESERVATIVE | [Cosmetic Ingredient Review (CIR)]
Imidazolidinyl urea (39236-46-9) | [InChI]
1S/C11H16N8O8/c20-2-18-4(6(22)16-10(18)26)14-8(24)12-1-13-9(25)15-5-7(23)17-11(27)19(5)3-21/h4-5,20-21H,1-3H2,(H2,12,14,24)(H2,13,15,25)(H,16,22,26)(H,17,23,27) | [Contact allergens]
Imidazolidinyl urea, a formaldehyde releaser related to
diazolidinyl urea (see above), is used as an antimicrobial
agent very active against Gram-positive and Gram-negative
bacteria, used as a synergist in combination with para-
bens. It is used as a preservative in aqueous products,
mainly in cosmetics, toiletries, and liquid soaps. | [InChIKey]
ZCTXEAQXZGPWFG-UHFFFAOYSA-N | [SMILES]
OCN1C(NC(=O)NCNC(=O)NC2N(CO)C(=O)NC2=O)C(=O)NC1=O | [LogP]
0.9 at 20℃ | [Uses]
imidazolidinyl urea is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential. In 2010, it was the tenth most frequently used preservative in the united States (parabens ranged from first to sixth place). generally, imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity. Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions, there is no detection of free formaldehyde release. of all the formaldehydereleasing preservatives, imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions. | [CAS DataBase Reference]
39236-46-9(CAS DataBase Reference) | [EPA Substance Registry System]
39236-46-9(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
solid with a mild odour | [Uses]
Antimicrobial | [Uses]
Antimicrobial preservative in cosmetics and topical pharmaceutical preparations. | [Description]
Imidazolidinyl urea, a formaldehyde releaser, is mainly contained in cosmetics and liquid soaps. | [Definition]
ChEBI: Imidazolidinyl urea is a member of ureas. It has a role as an antimicrobial agent. It is an antimicrobial preservative used in cosmetics. It acts as a formaldehyde releaser. | [Production Methods]
Imidurea is produced by the condensation of allantoin with
formaldehyde. | [General Description]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Flammability and Explosibility]
Nonflammable | [Pharmaceutical Applications]
N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is a broad-spectrum antimicrobial preservative used in cosmetics and topical pharmaceutical formulations; typical concentrations used are 0.03–0.5% w/w. It is effective between pH 3–9 and is reported to have synergistic effects when used with parabens.
| [Safety]
Imidurea is widely used in cosmetics and topical pharmaceutical
formulations, and is generally regarded as a nontoxic and
nonirritant material. However, there have been some reports of
contact dermatitis associated with imidurea, although these are
relatively few considering its widespread use in cosmetics.
Although imidurea releases formaldehyde, it does not appear to
be associated with cross-sensitization with formaldehyde or other
formaldehyde-releasing compounds.
LD50 (mouse, oral): 7.2 g/kg
LD50 (rabbit, skin): > 8 g/kg
LD50 (rat, oral): 11.3 g/kg | [storage]
Imidurea is hygroscopic and should be stored in a well-closed
container in a cool, dry place. | [Incompatibilities]
N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is incompatible with strong oxidants. It is compatible with other preservatives including sorbic acid and quaternary ammonium compounds. It is also compatible with other pharmaceutical and cosmetic excipients including proteins, nonionic surfactants, and lecithin.
| [Regulatory Status]
Included in the FDA Inactive Ingredients Database (topical
preparations). Accepted for use in cosmetics in Europe and the
USA. Included in the Canadian List of Acceptable Non-medicinal
Ingredients. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H317 | [Precautionary statements ]
P280 | [Hazard Codes ]
Xi | [Risk Statements ]
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
2
| [RTECS ]
YT7365000
| [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29332990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Skin Sens. 1B |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
|