| Identification | More | [Name]
Diazolidinylurea | [CAS]
78491-02-8 | [Synonyms]
DIAZOLIDINYL UREA
N-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)-urea
DiszolidinylUrea
germall11
hyl)-
imidazolidinylurea11
n-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-n,n’-bis(hydroxymethyl
n-(hydroxymethyl)-n-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-n’-(hyd
N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N’-(hydroxymethyl)urea
roxymethyl)urea
urea,n-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-n,n’-bis(hydroxymet
urea,n-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-n,n’-bis(hydroxymet
Urea,N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N’-bis(hydroxymethyl)-
1-[1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea
MicrocideIvtm
Germall
N-(HYDROXYMETHYL)-N-(1,3-DIHYDROXYMETHYL-2,5-DIOXO-4-IMIDA.
DIAZOLIDINYLUREA (GERMALL II)
1,3-Bis(hydroxymethyl)-5-[1,3-bis(hydroxymethyl)ureido]hydantoin
Germall Ⅱ | [EINECS(EC#)]
278-928-2 | [Molecular Formula]
C4H10N4O | [MDL Number]
MFCD00079129 | [Molecular Weight]
130.15 | [MOL File]
78491-02-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Boiling point ]
421.04°C (rough estimate) | [density ]
1.4734 (rough estimate) | [vapor pressure ]
0Pa at 20℃ | [refractive index ]
1.6590 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Water (Slightly) | [form ]
Solid | [pka]
11.22±0.46(Predicted) | [color ]
White to Off-White | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
1000g/L at 20℃ | [Merck ]
3000 | [Cosmetics Ingredients Functions]
PRESERVATIVE | [Cosmetic Ingredient Review (CIR)]
Diazolidinyl Urea (78491-02-8) | [InChI]
1S/C8H14N4O7/c13-1-9-7(18)10(2-14)5-6(17)12(4-16)8(19)11(5)3-15/h5,13-16H,1-4H2,(H,9,18) | [Contact allergens]
Diazolidinyl urea, a formaldehyde releaser, is contained mainly in cosmetics and toiletries and can be found in barrier creams. | [InChIKey]
SOROIESOUPGGFO-UHFFFAOYSA-N | [SMILES]
OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O | [LogP]
0.9 at 20℃ | [Uses]
diazolidinyl urea is an antiseptic and deodorizer. It is also a broadspectrum preservative against bacteria and fungi. generally, it is used in concentrations of 0.03 to 0.3 percent. It has been found that diazolidinyl urea is a stronger sensitizer than imidazolidinyl urea for people sensitive or allergic to formaldehyde. | [CAS DataBase Reference]
78491-02-8(CAS DataBase Reference) | [EPA Substance Registry System]
78491-02-8(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
Antimicrobial preservative in cosmetics and toiletries. | [Description]
Diazolidinyl urea, a formaldehyde re1easer, is mainly
contained in cosmetics and toiletries, and can be found
in barrier creams. | [Definition]
ChEBI: Diazolidinylurea is an imidazolidine-2,4-dione. | [Flammability and Explosibility]
Nonflammable | [Safety]
The Cosmetic Ingredient Review Expert Panel evaluated the safety of diazolidinyl urea and found that the ingredient is safe for current uses and concentrations, and it has low eye irritation potential. However, it has not been found to be sensitive to the skin or produce phototoxic effects. It’s use is restricted to maximum concentrations of 0.5%. This limit in concentration is mostly due to mild irritation that can occur on the skin in concentrations greater that this maximum. | [storage]
4°C, protect from light |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H319 | [Precautionary statements ]
P264-P280-P305+P351+P338-P337+P313 | [Hazard Codes ]
Xi | [Risk Statements ]
R43:May cause sensitization by skin contact. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
2
| [RTECS ]
YS2717000
| [TSCA ]
TSCA listed | [REACH Registrations]
Active | [HS Code ]
29339900 | [Toxicity]
LD50 orally in rats: 2.57 g/kg; dermally in rabbits: >2.0 g/kg (Berke, Rosen) |
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