| Identification | More | [Name]
1H-Pyrazole-1-carboxamidine hydrochloride | [CAS]
4023-02-3 | [Synonyms]
1-AMIDINOPYRAZOLE HYDROCHLORIDE
1-AMIDINOPYRAZOLE MONOHYDROCHLORIDE
1H-PYRAZOLE-1-CARBAMIDINE HCL
1H-PYRAZOLE-1-CARBOXAMIDINE HYDROCHLORIDE
1H-PYRAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE
AMIDINOPYRAZOLE HCL
N-GUANYLPYRAZOLE
PRAXADINE HYDROCHLORIDE
PYRAZOLE-1-CARBOXAMIDINE
PYRAZOLE CARBOXAMIDINE HCL
TIMTEC-BB SBB004101
Praxadine
(1H)-Pyrazole-1-carboxamidineHCl
1H-PYRAZOLE-1-CARBOXIMIDAMIDEHYDROCHLORIDE
1H-Pyrazole-1-carboximidamidemonohydrochloride
1H-PYRAZOLE-1-CARBOXAMIDINE, HYDROCHLORIDE 98+%
1H-pyrazole-1-carboxamidine
1H-PYRAZOLE-1-CARBAMIDINE HCI
1-Pyrazolecarboxamidine Hydrochloride
1-Amidinopyrazole hydrochloride, Praxadine | [EINECS(EC#)]
429-520-1 | [Molecular Formula]
C4H7ClN4 | [MDL Number]
MFCD00210087 | [Molecular Weight]
146.58 | [MOL File]
4023-02-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystals or crystalline | [Melting point ]
167-170 °C(lit.)
| [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Crystals or Crystalline Powder | [color ]
White to light yellow | [Water Solubility ]
Soluble | [Usage]
A stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. Useful reagent in peptide synthesis | [BRN ]
5448758 | [InChI]
InChI=1S/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H | [InChIKey]
RBZRMBCLZMEYEH-UHFFFAOYSA-N | [SMILES]
N1(C(N)=N)C=CC=N1.[H]Cl | [CAS DataBase Reference]
4023-02-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R36/37:Irritating to eyes and respiratory system .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [F ]
10-21 | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Sens. 1
STOT RE 2 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystals or crystalline | [Uses]
1H-Pyrazole-1-carboxamidine hydrochloride is a stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. 1H-Pyrazole-1-carboxamidine hydrochloride is a useful reagent in peptide synthesis
| [General Description]
1H-Pyrazole-1-carboxamidine hydrochloride, a pyrazole derivative, is a heterocyclic compound. It is widely used in drug syntheses studies. Pyrazole ring forms the main core of various nonsteroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. | [Synthesis]
Pyrazole (1.634 g, 24 mmol) and cyanamide (1 g, 24 mmol) were dissolved in 1,4-dioxane (24 mL), followed by the addition of 4 M hydrochloric acid (6 mL) to the 1,4-dioxane solution. The reaction mixture was stirred under reflux conditions for 1 hour. Upon completion of the reaction, the reaction mixture was placed in an ice-water bath and the product was induced to recrystallize by the addition of ether. The yield of the final product was 43%. | [References]
[1] Journal of Organic Chemistry, 1992, vol. 57, # 8, p. 2497 - 2502
[2] Organic Letters, 2004, vol. 6, # 26, p. 4925 - 4927
[3] Patent: KR101808950, 2017, B1. Location in patent: Paragraph 0233-0236
[4] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 24, p. 2771 - 2774
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 812 - 820 |
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