| Identification | Back Directory | [Name]
DIMETHYL-W84 DIBROMIDE | [CAS]
402475-33-6 | [Synonyms]
DIMETHYL-W84 DIBROMIDE
DimethylW84 (dibromide),Dimethyl W84 (dibromide),Dimethyl-W-84 (dibromide)
6-[dimethyl-[3-(5-methyl-1,3-dioxoisoindol-2-yl)propyl]azaniumyl]hexyl-dimethyl-[3-(5-methyl-1,3-dioxoisoindol-2-yl)propyl]azanium | [Molecular Formula]
C34H48BrN4O4+ | [MDL Number]
MFCD08702721 | [MOL File]
402475-33-6.mol | [Molecular Weight]
656.69 |
| Hazard Information | Back Directory | [Description]
Dimethyl-W84 is a selective allosteric modulator of the M2 muscarinic acetylcholine receptor. It hinders the dissociation of the orthosteric antagonist N-methylscopolamine from the M2 receptor with an EC50 value of 3 nM. | [Uses]
Dimethyl-W84 dibromide is a potent allosteric modulator of muscarinic receptors also selective for M2-receptors. | [References]
[1] C TR?NKLE. Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors.[J]. Molecular Pharmacology, 1998, 54 1: 139-145. DOI: 10.1124/mol.54.1.139
[2] CHRISTIAN TR?NKLE. Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.[J]. Molecular Pharmacology, 2003, 64 1: 180-190. DOI: 10.1124/mol.64.1.180 |
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