| Identification | More | [Name]
Tosyl isocyanate | [CAS]
4083-64-1 | [Synonyms]
4-METHYLBENZENE-1-SULFONYL ISOCYANATE
4-TOLUENESULFONYL ISOCYANATE
P-TOLUENESULFONYL ISOCYANATE
P-TOLUENESULPHONYL ISOCYANATE
PTSI
TOLUENE-4-SULFONYL ISOCYANATE
TOSYL ISOCYANATE
4-Isocyanatosulphonyltoluene,
4-methyl-benzenesulfonylisocyanat
4-methyl-Benzenesulfonylisocyanate
4-Methylphenylsulfonyl isocyanate
Benzenesulfonyl isocyanate, 4-methyl-
Benzenesulfonylisocyanate,4-methyl-
p-Methylphenylsulfonyl isocyanate
p-Toluenesulfonic acid, anhydride with isocyanic acid
p-Toluensulfonyl isocyanate
p-Tolylsulfonyl isocyanate
p-Tosyl isocyanate
Sulfone, isocyanato tolyl
P-toluenesulfony6l isocyanate | [EINECS(EC#)]
223-810-8 | [Molecular Formula]
C8H7NO3S | [MDL Number]
MFCD00002030 | [Molecular Weight]
197.21 | [MOL File]
4083-64-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R14:Reacts violently with water.
R36/37/38:Irritating to eyes, respiratory system and skin .
R42:May cause sensitization by inhalation. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S30:Never add water to this product . | [RIDADR ]
UN 2206 6.1/PG 3
| [WGK Germany ]
1
| [RTECS ]
DB9032000 | [F ]
10 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29309090 |
| Hazard Information | Back Directory | [Hazard]
Moderately toxic by ingestion. Low toxicity by inhalation. A mild skin and moderate eye
irritant. | [Chemical Properties]
clear liquid | [Uses]
p-Toluenesulfonyl isocyanate is a reagent used to prepare acetylated syn-1,2-diols,1 oxazolidin-2-ones,2 2,3-diamino acids,3 and N-tosylcarbonamides.4
| [Synthesis Reference(s)]
Tetrahedron Letters, 35, p. 9609, 1994 DOI: 10.1016/0040-4039(94)88523-0 | [General Description]
p-Toluenesulfonyl isocyanate undergoes palladium-catalyzed bis-allylation reaction with allylstannanes and allyl chlorides. | [Synthesis]
Add the organic azide (0.75 mmol), Pd(OAc)2
(5.6 mg, 5 mol%) to an oven-dried Schlenk tube (10 mL). Purge the tube
and backfill with CO (three cycles) from a balloon. Inject anhydrous
MeCN (3.0 mL) into the tube. Stir at 80??C for 4 h under CO atmosphere
(balloon). Concentrate the mixture under reduced pressure. Purify the
residue by column chromatography (petroleum ether/EtOAc 3:1.-.1:1).
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