| Identification | More | [Name]
2-Chloro-5-hydroxypyridine | [CAS]
41288-96-4 | [Synonyms]
2-CHLORO-5-HYDROXYPYRIDINE
2-CHLORO-5-PYRIDINOL
3-PYRIDINOL, 6-CHLORO-
6-Chloro-3-pyridinol
6-CHLOROPYRIDIN-3-OL
2-Chloro-5-Pyridol
2-Chloropyridin-5-ol
3-Pyridinol,6-chloro-(9CI)
2-Chloro-5-hydropyridine
2-CHLORO-5-HYDROXYPYRIDINE 98%
2-CHLORO-5-HYDROXYPYRIDINE 99+% | [EINECS(EC#)]
670-289-1 | [Molecular Formula]
C5H4ClNO | [MDL Number]
MFCD00234050 | [Molecular Weight]
129.54 | [MOL File]
41288-96-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow Cryst | [Melting point ]
155-158°C | [Boiling point ]
351.9±22.0 °C(Predicted) | [density ]
1.392±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [pka]
8.69±0.10(Predicted) | [color ]
Light yellow to Brown | [InChI]
InChI=1S/C5H4ClNO/c6-5-2-1-4(8)3-7-5/h1-3,8H | [InChIKey]
KVCOOWROABTXDJ-UHFFFAOYSA-N | [SMILES]
C1=NC(Cl)=CC=C1O | [CAS DataBase Reference]
41288-96-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow Cryst | [Synthesis]
11B. 6-Chloropyridin-3-yl acetate (11.1 g, 64.7 mmol) from step 11a was dissolved in methanol at room temperature, followed by addition of solid potassium carbonate (4.47 g, 32.4 mmol). The reaction mixture was stirred for 2 hours and the volatiles were removed under reduced pressure. The residue was diluted with ether and water, and the aqueous phase was neutralized to pH 7 by addition of aqueous 1 N hydrochloric acid.The organic and aqueous layers were separated and the aqueous phase was extracted twice with ether. The organic extracts were combined, dried over magnesium sulfate and concentrated to give 2-chloro-5-hydroxypyridine as a white solid (8.03 g, 96% yield): melting point 155 °C; 1H NMR (CD3OD, 300 MHz) δ 7.20-7.28 (m, 2H), 7.88 (m, 1H); mass spectrum (CI/NH3) m/z: 130,132 (M+H) +; 147,149 (M+NH4)+. | [References]
[1] Patent: US6696439, 2004, B1. Location in patent: Page column 20
[2] Patent: US6001849, 1999, A
[3] Tetrahedron Letters, 2003, vol. 44, # 4, p. 725 - 728
[4] Patent: EP1698626, 2006, A1. Location in patent: Page/Page column 24
[5] Patent: WO2004/72072, 2004, A1. Location in patent: Page 85 |
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