| Identification | More | [Name]
2-Chloro-5-nitropyridine | [CAS]
4548-45-2 | [Synonyms]
2-CHLORO-5-HYDROXYPYRIDINE
2-CHLORO-5-PYRIDINOL
3-PYRIDINOL, 6-CHLORO-
6-CHLOROPYRIDIN-3-OL
2-chloro-5-nitro-pyridin
Chloronitropyridine,99%
2-choro-5-nitropyridine
2-CHLORO-5-NITROPYRIDINE (NON-REGULATED)
2-CHLORO-5-NITROPYRIDINE (REGULATED)
2-CHLORO-5-NITROPYRIDINE 99+%
2-Chloro-5-nitropyridine
3-Nitro-6-chloropyridine
5-Nitro-2-chloropyridine
6-Chloro-3-nitropyridine | [EINECS(EC#)]
224-908-3 | [Molecular Formula]
C5H3ClN2O2 | [MDL Number]
MFCD00234050 | [Molecular Weight]
158.54 | [MOL File]
4548-45-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal | [Melting point ]
105-108 °C (lit.) | [Boiling point ]
256.6±20.0 °C(Predicted) | [density ]
1.6616 (rough estimate) | [refractive index ]
1.5500 (estimate) | [Fp ]
158°C | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Crystalline Powder | [pka]
-4.22±0.10(Predicted) | [color ]
Light yellow to beige | [Water Solubility ]
Solubility in hot methanol. Insoluble in water. | [Detection Methods]
HPLC,GC,NMR | [BRN ]
120453 | [InChIKey]
BAZVFQBTJPBRTJ-UHFFFAOYSA-N | [CAS DataBase Reference]
4548-45-2(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Chloro-5-nitropyridine(4548-45-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
US7175000
| [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal | [Uses]
2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate. | [Synthesis]
Into a 500 ml four-necked flask equipped with a thermometer, stirring and reflux condenser, 50 g of phosphorus oxychloride, 14.0 g (0.1 mole) of 2-hydroxy-5-nitropyridine prepared in Example 1, 25.0 g (0.12 Mol) Phosphorus pentachloride,Stir and react at 100-105°C for 5 hours,Then the phosphorus oxychloride was recovered by distillation under reduced pressure, and the remainder was slowly poured into 120 grams of ice water, fully stirred, and then a 40wt% aqueous sodium hydroxide solution was neutralized to a pH of 8-9.Separate the layers, extract the aqueous layer with dichloromethane three times, 60 grams each time, combine the organic phases,Washed with 20 grams of saturated brine, then dried with 2.0 grams of anhydrous sodium sulfate, distilled to recover dichloromethane, and dried to obtain 15.1 grams of 2-chloro-5-nitropyridine (I), yield 95.3%, gas purity 99.8 %. | [Purification Methods]
It crystallises from *benzene or *benzene/pet ether. [Beilstein 20/5 V 452.] |
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