| Identification | More | [Name]
STACHYDRINE HYDROCHLORIDE | [CAS]
4136-37-2 | [Synonyms]
STACHYDRINE HYDROCHLORIDE
(S)-2-carboxy-1,1-dimethylpyrrolidinium chloride
StachydrineHCl
Stachydrine hydrichloride | [EINECS(EC#)]
223-957-8 | [Molecular Formula]
C7H14ClNO2 | [MDL Number]
MFCD00060174 | [Molecular Weight]
179.64 | [MOL File]
4136-37-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
225°C | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
Soluble in water | [Merck ]
8771 | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C7H13NO2.ClH/c1-8(2)5-3-4-6(8)7(9)10;/h6H,3-5H2,1-2H3;1H | [InChIKey]
DUNMULOWUUIQIL-UHFFFAOYSA-N | [SMILES]
C1(CCC[N+]1(C)C)C([O-])=O.Cl | [CAS DataBase Reference]
4136-37-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338 | [Risk Statements ]
R20:Harmful by inhalation. | [Safety Statements ]
S22:Do not breathe dust .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, easily soluble in methanol and water, derived from motherwort. | [Uses]
Stachydrine Chloride is a constituent of the Chinese herb leonurus heterophyllus sweet. its used in clinics to support blood circulation and dispel blood stasis. | [Biological Activity]
stachydrine is an anti-metastatic agent.stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of c. leonurus, and many other asian plants and fruits. | [in vitro]
the aim of a previous study was to investigate the effects of stachydrine (sta) on norepinephrine (ne) induced hypertrophy and the changes of calcium transients in neonatal rat cardiomyocytes. results showed that ne treatment could increase protein synthesis, cell surface area, the expression level of β-mhc and β/α-mhc ratio and these effects were attenuated by sta treatment. in addition, ne-induced hypertrophy was associated with accelerated decay of ca2+-transient, increased phospholamban expression, increased ca2+-transient amplitude, hyper-phosphorylation, increased intracellular camp level, as well as pka overactivation. all of these effects could be inhibited by sta treatment significantly [1]. | [in vivo]
previous study evaluated the effect of stachydrine on the expression of caspase-9 and 12 in rats with unilateral ureteral obstruction. results showed that degree of renal interstitial fibrosis, serum creatinine, blood urea nitrogen, the renal tubular interstitial damage index, and expression of caspase-9 and 12 in the stachydrine-treatment groups were significantly decreased [2]. | [target]
IL Receptor | T-bet | RORγt | GATA-3 | Foxp3 | [IC 50]
p65; Human Endogenous Metabolite | [References]
[1] zhang, c. ,shan, x.-l.,liao, y.-l., et al. effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients. bmc complement. altern. med. 14, 474 (2014).
[2] zhang c, lu y, zhou yj, tong qq, qu c, kang tj. the effect of stachydrine on the expression of caspase-12 in rats with unilateral ureteral obstruction. j urol. 2014 nov;192(5):1549-54. |
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