| Identification | More | [Name]
(R)-2-Methyl-pyrrolidine | [CAS]
41720-98-3 | [Synonyms]
D-2-METHYLPYRROLIDINE
METHYLPYRROLIDINE(S-2-)
(R)-2-METHYL-PYRROLIDINE
(S)-(+)-2-METHYLPYRROLIDINE
(S)-2-METHYL-PYRROLIDINE
(2R)-2-Methylpyrrolidine
(2R)-2-Methylpyrrolidinehydrochloride
(2R)-2-Methylpyrrolidine hcl | [Molecular Formula]
C5H11N | [MDL Number]
MFCD07779425 | [Molecular Weight]
85.15 | [MOL File]
41720-98-3.mol |
| Chemical Properties | Back Directory | [Boiling point ]
94 °C(Press: 728 Torr) | [density ]
0.842 | [refractive index ]
1.4353 | [Fp ]
45 ºF | [storage temp. ]
2-8°C | [form ]
oil | [pka]
10.93±0.10(Predicted) | [color ]
Colourless to pale yellow | [Water Solubility ]
Insoluble in water. | [InChI]
InChI=1S/C5H11N/c1-5-3-2-4-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1 | [InChIKey]
RGHPCLZJAFCTIK-RXMQYKEDSA-N | [SMILES]
N1CCC[C@H]1C | [CAS DataBase Reference]
41720-98-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C,F | [Risk Statements ]
R11:Highly Flammable.
R22:Harmful if swallowed.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2924 | [WGK Germany ]
3 | [Hazard Note ]
Corrosive/Highly Flammable | [HazardClass ]
3 | [PackingGroup ]
Ⅱ | [HS Code ]
29339900 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Flam. Liq. 2
Skin Corr. 1B |
| Hazard Information | Back Directory | [Uses]
Building block used in a multikilogram synthesis of a chiral naphthalenoid histamine receptor antagonist. | [Uses]
It is used as a building block used in a multikilogram synthesis of a chiral naphthalenoid histamine receptor antagonist. | [Application]
(R)-2-Methyl-pyrrolidine, an optically active amine that can be used as a key building block to synthesize:
4,5-fused pyridazinone derivatives are applicable as potent histamine H3 receptor antagonists.
Naphthalenoid histamine H3 receptor antagonist.
Pyrrolo[2,3-d]pyrimidine derivatives as potent inhibitors of leucine-rich repeat kinase 2. | [Definition]
ChEBI: (R)-2-methylpyrrolidine is a 2-methylpyrrolidine that has (R)-configuration. It is a conjugate base of a (R)-2-methylpyrrolidinium. | [Synthesis]
The general procedure for the synthesis of 2-methylpyrrolidine from 2-methylpyrroline was as follows: the whole-cell biotransformation reaction was carried out in sodium phosphate buffer (100 mM, pH 7.0) at 30 °C and 1000 rpm. Freshly harvested resting cells of E. coli BL21(DE3) expressing IRED with a final OD600nm adjusted to 90 were used.The reaction mixture contained 2.5 or 5 mM of imine substrate and 50 mM of glucose. | [References]
Synthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H3 receptor antagonists. DOI:10.1016/j.bmcl.2011.08.045
Efficient and Practical Synthesis of (R)-2-Methylpyrrolidine DOI:10.1021/jo060319n
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