| Identification | More | [Name]
2,4-Dichlorothiazole | [CAS]
4175-76-2 | [Synonyms]
2,4-DICHLORO-1,3-THIAZOLE
2,4-DICHLOROTHIAZOLE
2,4-DICHLOROTHIAZOLE,98.0+%(GC)
2,4-Dichlorothiazole ,98% | [Molecular Formula]
C3HCl2NS | [MDL Number]
MFCD08691358 | [Molecular Weight]
154.02 | [MOL File]
4175-76-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
44 °C | [Boiling point ]
184 °C | [density ]
1.603±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
-1.93±0.10(Predicted) | [color ]
White to Light yellow to Light orange | [Detection Methods]
GC,NMR | [InChIKey]
ICETWLGKJXCIDX-UHFFFAOYSA-N | [CAS DataBase Reference]
4175-76-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Synthesis]
The general procedure for the synthesis of 2,4-dichlorothiazole from 2,4-thiazolidinedione was as follows: 2,4-thiazolidinedione (50 g, 0.43 mol) was dissolved in phosphorus trichloride (240 mL) and cooled to 5 °C. Pyridine (34 mL, 0.43 mol) was added slowly over 15 minutes. The reaction mixture was heated to 125°C and maintained at this temperature for 4 hours. After completion of the reaction, it was cooled to 22°C. Excess phosphorus trichloride was removed by vacuum distillation. The residue was slowly poured into water (1 L) pre-cooled to 5°C. The aqueous phase was extracted with dichloromethane (3 x 400mL). The organic phases were combined and the solvents were evaporated to give the target product 2,4-dichlorothiazole (50 g, 76% yield).EI/MS m/z: (35Cl35Cl/35Cl37Cl/37Cl37Cl)153/155/157(M+1)+. | [References]
[1] Patent: WO2008/36579, 2008, A1. Location in patent: Page/Page column 36-37
[2] Patent: US2005/234046, 2005, A1. Location in patent: Page/Page column 60
[3] Journal of the American Chemical Society, 2013, vol. 135, # 5, p. 1986 - 1996
[4] Patent: WO2013/149362, 2013, A1. Location in patent: Page/Page column 55
[5] Patent: WO2017/155909, 2017, A1. Location in patent: Paragraph 0159 |
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