| Identification | Back Directory | [Name]
3-methylmorpholine | [CAS]
42185-06-8 | [Synonyms]
3-methylmorpholine
Morpholine, 3-methyl-
3-Methylmorpholine 97%
3-MethylMorpholine hcl h2o | [Molecular Formula]
C5H11NO | [MDL Number]
MFCD09054773 | [MOL File]
42185-06-8.mol | [Molecular Weight]
101.15 |
| Chemical Properties | Back Directory | [Boiling point ]
133-134 °C | [density ]
0.9591 g/cm3(Temp: 16 °C) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
9.03±0.40(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
A solution of 4-(4-methoxybenzyl)-3-methylmorpholine (7 g, 31.53 mmol, 1.00 eq.) in methanol (70 mL) was added to a 250 mL round-bottom flask under nitrogen protection. A 10% palladium-carbon catalyst (2 g) was then added. After passing hydrogen (H2), the reaction mixture was stirred in an oil bath at 50 °C overnight. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to give 2.1 g (66% yield) of 3-methylmorpholine as a yellow oil.LC-MS analysis: (ES, m/z): 102 [M + H]+. | [References]
[1] Patent: WO2011/28947, 2011, A2. Location in patent: Page/Page column 154; 157 |
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