| Identification | More | [Name]
HYOSCINE HYDROCHLORIDE | [CAS]
55-16-3 | [Synonyms]
HYOSCINE HYDROCHLORIDE
SCOPINE TROPATE
SCOPINE TROPATE HYDROCHLORIDE
(-)-SCOPOLAMINE HYDROCHLORIDE
SCOPOLAMINE HYDROCHLORIDE
0(sup2,4))non-7-ylester,hydrochloride,(7(s)-(1-alpha,2-beta,4-beta,5-alpha
5-alpha-h-tropan-3-alpha-ol,6-beta,7-beta-epoxy-1-alpha-(-)-tropate(est
chlorhydratedescopolamine
er),hcl,
(−
)-Scopolamine hydrochloride
ScopolamineSeries
HYPACONITINE(P)
(-)-Scopolaminhydrochlorid
Hyoscine hydrochloride, Scopine tropate | [EINECS(EC#)]
200-225-6 | [Molecular Formula]
C17H22ClNO4 | [MDL Number]
MFCD00058096 | [Molecular Weight]
339.81 | [MOL File]
55-16-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S25:Avoid contact with eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1544 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
CY1634501
| [F ]
3-8 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents. | [Uses]
Antiemetic;Non-selective muscarinic antagonist | [Biochem/physiol Actions]
Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit. | [in vivo]
Scopolamine induces memory impairment associated with attenuation of cholinergic neurotransmission, as well as an increases of processes connected with oxidative stress in the brain[3]. | Animal Model: | Naive male Swiss mice weighing 20-25[3] | | Dosage: | 1 mg/kg | | Administration: | Administered intraperitoneally (i.p.); to measure the memory acquisition processes, Scopolamine was administered 20 min before the pretest; to measure the memory consolidation processes, Scopolamine was administered immediately after the pretest | | Result: | In scopolamine-treated group, there was a significant decrease in the index of latency (IL) value as compared with the saline-treated mice, indicating that scopolamine at the used dose impaired acquisition of memory and learning. |
| [IC 50]
5-HT3 Receptor: 2.09 μM (IC50) |
|
|