| Identification | More | [Name]
6-Chlorouracil | [CAS]
4270-27-3 | [Synonyms]
4-CHLORO-2,6-DIHYDROXYPYRIMIDINE
4-CHLOROURACIL
6-CHLORO-2,4(1H,3H)-PYRIMIDINEDIONE
6-CHLORO-2,4-DIHYDROXYPYRIMIDINE
6-CHLOROURACIL
AURORA KA-4918
SPECS AB-323/25048125
TIMTEC-BB SBB004104
2,4(1H,3H)-Pyrimidinedione, 6-chloro-
2,4-Pyrimidinediol,6-chloro-
6-Chloro-2,4-dihydroxypyrimidine~4-Chlorouracil
2,4(1H,3H)-Pyrimidinedione, 6-chloro-(9CI)
6-Chlorouracil,98+%
4-Chloro-2,6-dihydroxypyrimidine, 6-Chloro-2,4-dihydroxypyrimidine, 6-Chlorouracil | [EINECS(EC#)]
224-258-0 | [Molecular Formula]
C4H3ClN2O2 | [MDL Number]
MFCD00014595 | [Molecular Weight]
146.53 | [MOL File]
4270-27-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
290-295°C | [Boiling point ]
300°C | [density ]
1.61±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Soluble in Ammonium Hydroxide | [form ]
Solid | [pka]
6.24±0.10(Predicted) | [color ]
White | [Water Solubility ]
4.885g/L(25 ºC) | [BRN ]
120492 | [InChI]
InChI=1S/C4H3ClN2O2/c5-2-1-3(8)7-4(9)6-2/h1H,(H2,6,7,8,9) | [InChIKey]
PKUFNWPSFCOSLU-UHFFFAOYSA-N | [SMILES]
C1(=O)NC(Cl)=CC(=O)N1 | [CAS DataBase Reference]
4270-27-3(CAS DataBase Reference) | [NIST Chemistry Reference]
6-Chlorouracil(4270-27-3) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Uses]
6-Chlorouracil acts as an inhibitor of yeast alcohol dehydrogenase (ADH-H). 6-Chlorouracil is a potential inhibitor of DNA repair glycosylases. | [Uses]
Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines. |
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