| Identification | More | [Name]
Nandrolone | [CAS]
434-22-0 | [Synonyms]
17BETA-HYDROXY-19-NORANDROST-4-EN-3-ONE
17BETA-HYDROXY-4-ESTREN-3-ONE
17b-hydroxyestra-4-en-3-one
17-HYDROXY-13-METHYL-2,6,7,8,9,10,11,12,14,15,16,17-DODECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-ONE, 5-ANDROSTENEDIONE
19-NOR-4-ANDROSTEN-17-BETA-OL-3-ONE
19-NORANDROSTENOLONE
19-NORTESTOSTERONE
4-ESTREN-17BETA-OL-3-ONE
NADROLONE
NANDROLON
NANDROLONE
NORANDROSTENEDIONE
NORANDROSTENOLONE
NORTESTOSTERONE, 19-
(17beta)-estr-4-en-3-on
17-beta-hydroestr-4-en-3-one
17beta-hydroxy-19-nor-4-androsten-3-one
17-beta-hydroxy-estr-4-en-3-on
17beta-hydroxy-estr-4-en-3-on
menidrabol | [EINECS(EC#)]
207-101-0 | [Molecular Formula]
C18H26O2 | [MDL Number]
MFCD00003664 | [Molecular Weight]
274.4 | [MOL File]
434-22-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
120-125 °C
| [alpha ]
D22 +55° (c = 0.93 in chloroform) | [Boiling point ]
357.38°C (rough estimate) | [density ]
1.0528 (rough estimate) | [refractive index ]
1.4800 (estimate) | [Fp ]
2℃ | [storage temp. ]
Controlled Substance, -20°C Freezer | [solubility ]
Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
15.06±0.40(Predicted) | [color ]
Dimorphic crystals from CH2Cl2/Et2O | [Water Solubility ]
3.09g/L(25 ºC) | [Usage]
An anabolic steroid.
Controlled substance (anabolic steroid) | [Merck ]
6365 | [BRN ]
2055849 | [Henry's Law Constant]
3.7×103 mol/(m3Pa) at 25℃, HSDB (2015) | [Major Application]
clinical testing | [InChI]
1S/C18H26O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-17,20H,2-9H2,1H3/t13-,14+,15+,16-,17-,18-/m0/s1 | [InChIKey]
NPAGDVCDWIYMMC-IZPLOLCNSA-N | [SMILES]
CC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2O | [CAS DataBase Reference]
434-22-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Nandrolone(434-22-0) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS08 | [Signal word ]
Danger | [Hazard statements ]
H351-H360FD | [Precautionary statements ]
P201-P202-P280-P308+P313-P405-P501 | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 1648 3 / PGII | [WGK Germany ]
3
| [RTECS ]
KG7964000
| [REACH Registrations]
Inactive | [HS Code ]
29372900 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2 | [Hazardous Substances Data]
434-22-0(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Originator]
Durabolin,Organon,US,1959 | [Uses]
An anabolic steroid.
Controlled substance (anabolic steroid) | [Definition]
ChEBI: A 3-oxo Delta4-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17. | [Manufacturing Process]
An ice-cold solution of 1.5 grams of 19-nortestosterone and 1.5 ml of dry pyridine in 10 ml of dry benzene is prepared and a solution of 1.5 ml of β-
phenylpropionyl chloride in 5 ml of dry benzene is added dropwise over a
period of about 2 minutes with stirring. The resulting mixture is allowed to
stand overnight under an atmosphere of nitrogen and then washed
successively with cold 5% aqueous hydrochloric acid solution, cold 2.5%
aqueous sodium hydroxide solution, and water. After drying over anhydrous
sodium sulfate, the solvent is evaporated to give an almost colorless oil.
Recrystallization from methanol gives white crystals of 19-nortestosterone 17-
β-phenylpropionate, MP 91° to 92.5°C. | [Therapeutic Function]
Anabolic | [Mechanism of action]
Nandrolone facilitates formation of body muscle mass and strengthens the process of
osseous tissue development. The main indications for using nandrolone, as well as other
anabolic steroids, are abnormal protein anabolism, asthenia, diseases accompanied by protein loss, adrenal insufficiency, steroid diabetes, and prolonged condition of sluggishness. | [Safety Profile]
Experimental reproductiveeffects. When heated to decomposition it emits acridsmoke and irritating fumes. | [Synthesis]
Nandrolone, 17|?-hydroxyester-4-en-3-one (29.1.7), is made from estradiol
(28.1.17). The phenol hydroxyl group undergoes methylation by dimethylsulfate in the
presence of sodium hydroxide, forming the corresponding methyl ether (29.3.1), and then
the aromatic ring is reduced by lithium in liquid ammonia, which forms an enol ether
(29.3.2). Hydrolyzing this compound with a mixture of hydrochloric and acetic acids leads
to the formation of a keto group, and simultaneous isomerization of the double bond from
C5¨CC10 to position C4¨CC5 gives the desired nandrolone (29.3.3) [16¨C19]. Upon necessity of
using it in the form of acid esters, the product is acylated by corresponding acid derivatives.
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