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58-18-4

58-18-4 Structure

58-18-4 Structure
IdentificationMore
[Name]

17-Methyltestosterone
[CAS]

58-18-4
[Synonyms]

17ALPHA-METHYL-4-ANDROSTEN-17BETA-OL-3-ONE
17ALPHA-METHYLTESTOSTERONE
17A-METHYL-1-TESTOSTERONE
17BETA-HYDROXY-17ALPHA-METHYL-4-ANDROSTEN-3-ONE
17-METHYLTESTOSTERONE
4-ANDROSTEN-17ALPHA-METHYL-17BETA-OL-3-ONE
MESTERONE
METANDREN
METHYLTESTOSTERONE
17alpha-Methyl-3-oxo-4-androsten-17beta-ol
17alpha-methyl-delta-androsten-17beta-ol-3-one
17-beta-hydroxy-17-methyl-androst-4-en-3-on
17beta-hydroxy-17-methyl-androst-4-en-3-on
17-beta-Hydroxy-17-methylandrost-4-en-3-one
17beta-hydroxy-17-methylandrost-4-en-3-one
17-Hydroxy-17-methylandrost-4-en-3-one
17-Methyltestosteron
4-androstene-17-alpha-methyl-17-beta-ol-3-one
4-Androstene-17alpha-methyl-17beta-ol-3-one
Andrometh
[EINECS(EC#)]

200-366-3
[Molecular Formula]

C20H30O2
[MDL Number]

MFCD00003655
[Molecular Weight]

302.45
[MOL File]

58-18-4.mol
Chemical PropertiesBack Directory
[Appearance]

white to slightly yellowish-white crystalline
[mp ]

162-168 °C(lit.)
[alpha ]

79 º (c=1, alcohol)
[Fp ]

5 °C
[storage temp. ]

2-8°C
[solubility ]

H2O: ≤0.5 mg/mL
[form ]

solid (photosensitive)
[color ]

white
[Merck ]

13,6148
[CAS DataBase Reference]

58-18-4(CAS DataBase Reference)
[NIST Chemistry Reference]

17(Alpha)-methyl-delta4-androsten-17-(beta)-ol-3-one(58-18-4)
[EPA Substance Registry System]

58-18-4(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

T,Xn,F,Xi
[Risk Statements ]

R45:May cause cancer.
R63:Possible risk of harm to the unborn child.
R22:Harmful if swallowed.
R20:Harmful by inhalation.
R19:May form explosive peroxides.
R11:Highly Flammable.
R61:May cause harm to the unborn child.
R60:May impair fertility.
R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S53:Avoid exposure-obtain special instruction before use .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust .
[RIDADR ]

3249
[WGK Germany ]

3
[RTECS ]

BV8400000
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

29372900
[Safety Profile]

Poison by intraperitoneal route. Moderately toxic by ingestion. Human teratogenic effects by ingestion: developmental abnormalities of the urogenital system. Experimental teratogenic and reproductive effects. Human systemic effects: cholestatic jaundce, weight loss or decreased weight gain. Questionable human carcinogen producing liver tumors. A synthetic androgenic steroid. When heated to decomposition it emits acrid smoke and irritating fumes.
[Hazardous Substances Data]

58-18-4(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

16-Dehydropregnenolone acetate-->Aluminium isopropoxide-->Epiandrosterone
[Preparation Products]

Bolasterone
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

17-Methyltestosterone(58-18-4).msds
Questions And AnswerBack Directory
[Overview]

17-Methyltestosterone, a synthetic derivative of testosterone, is an androgen and anabolic steroid (AAS) medication. It is mainly used in the treatment of low testosterone levels in men, delayed puberty in boys, at low doses as a component of menopausal hormone therapy for menopausal symptoms like hot flashes, osteoporosis, and low sexual desire in women, and to treat breast cancer in women (1-3). It appears as white or creamy white crystals or powder, which is soluble in various organic sol vents but is practically insoluble in water. It should be subject to oral administration.
Methyltestosterone was first discovered in 1935 and was introduced for medical use in 1936. It was synthesized shortly after the discovery of testosterone, being one of the first synthetic AAS drug. 17-Methyltestosterone, beyond its medical function, can also be used to improve physique and performance, although it is not as commonly used as other AAS for such purposes due to its androgenic effects, estrogenic effects, and risk of liver damage. The drug is a controlled substance in many countries and so non-medical use is generally illicit.
[Indication and administration]

It has been used in the treatment of various symptoms such as hypogonadism, cryptorchidism, delayed puberty, and erectile dysfunction in males, and in low doses to treat menopausal symptoms (specifically for osteoporosis, hot flashes, and to increase libido and energy), postpartum breast pain and engorgement.
In US, 17-Methyltestosterone is an anabolic steroid hormone that majorly used to treat men with a testosterone deficiency, hypogonadism and delayed puberty. Hypogonadism include both primary type and hypogonadotropic type: the former one can be caused by cryptorchidism, bilateral torsions, orchitis, vanishing testis syndrome; or orchidectomy. The later one includes idiopathic gonadotropin or LHRH deficiency, or pituitary hypothalamic injury from tumors, trauma, or radiation. It is also used in women to treat breast cancer, breast pain, swelling due to pregnancy, and with the addition of estrogen it can treat symptoms of menopause. It has also been used in combination with esterified estrogens for the treatment of moderate to severe vasomotor symptoms associated with menopause in females.
17-Methyltestosterone is administered orally. The suggested dosage varies depending on the age, sex, and diagnosis of the individual patient. Dosage is adjusted according to the patient's response and the appearance of adverse reactions. Replacement therapy in androgen-deficient males usually demands 10 to 50 mg of 17-Methyltestosterone daily. However, the chronological and skeletal ages must be taken into consideration both in determining the initial dose and in adjusting the dose. Doses used in the treatment of the delayed puberty generally are in the lower range of that given above, and for a limited duration, for example 4 to 6 months. For the treatment of women breast cancer, the dosage of 17-Methyltestosterone in females is from 50-200 mg daily.
[Mode of action]

17-Methyltestosterone take effects through two main mechanisms: activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors.
17-Methyltestosterone can enter into the target tissue cells, binding to the androgen receptor, or being reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly, yielding a even stronger androgenic potency. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA, which is called hormone response elements (HREs). This process regulates the transcriptional activity of various genes, further producing the androgen effects.
[Adverse reactions]

17-methyltestosterone can cause various kinds of adverse reactions. Common side effects include increased facial/body hair growth, scalp hair loss, increased aggressiveness, skin, acne, seborrhea, and sex drive and spontaneous erections. There are also some kinds of estrogenic side effects such as breast tenderness, gynecomastia, fluid retention, and edema. Men can suffer hypogonadism, testicular atrophy, and reversible infertility. Women can sometimes suffer partially irreversible virilization including clitoromegaly, breast atrophy, voice deepening, hirsutism and muscle hypertrophy, as well as menstrual disturbances and reversible infertility.
17-methyltestosterone may also cause hepatotoxicity including elevated liver enzymes, cholestatic jaundice, peliosis hepatis, hepatomas, and hepatocellular carcinoma. It can also have adverse effect on the cardiovascular system such as causing erythropoiesis, increase hematocrit levels or even polycythemia, further leading to even thrombic events such as embolism and stroke. Finally, long-term treatment increase the risk of cancer. Some extreme cases also include hypomania/mania, depression, delusions, suicidality and psychosis.
[Warning and precaution]

People of the following cases should not use it: allergy; prostate cancer; male breast cancer, pregnant.
People with liver or kidney disease, an enlarged prostate, heart disease, congestive heart failure should use with caution.
[References]

  • Alexandre Hohl (6 April 2017). Testosterone: From Basic to Clinical Aspects. Springer. pp. 204–. ISBN 978-3-319-46086-4.
  • Shahidi NT (2001). "A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids". Clin Ther. 23 (9): 1355–90.
  • Shi, Y., et al. "Molecular identification of an androgen receptor and its changes in mRNA levels during 17α-methyltestosterone-induced sex reversal in the orange-spotted grouper Epinephelus coioides. " Comp Biochem Physiol B Biochem Mol Biol 163.1(2012):43-50.
  • Zheng, Z., B. A. Armfield, and M. J. Cohn. "Timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies." PNAS 112.52(2015):201515981.
  • Komada, S., et al. "Side gland of Suncus murinus, as a new model of sebaceous gland: 5α-reductase, androgen receptor, and nuclear androgen content in male and female animals." Archives of Dermatological Research 280.8(1989):487-493.
  • Kicman, A T (2008). "Pharmacology of anabolic steroids". British Journal of Pharmacology. 154 (3): 502–521.
  • Jeffrey K. Aronson (21 February 2009). Meyler's Side Effects of Endocrine and Metabolic Drugs. Elsevier. pp. 141–. ISBN 978-0-08-093292-7.
  • Benjamin J. Sadock; Virginia A. Sadock (26 December 2011). Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry. Lippincott Williams & Wilkins. ISBN 978-1-4511-7861-6.
  • Bird, D. R., and K. D. Vowles. "Liver damage from long-term methyltestosterone. " Inpharma 310.8032(1977):261-263.
 
Spectrum DetailBack Directory
[Spectrum Detail]

17-Methyltestosterone(58-18-4) 13C NMR
17-Methyltestosterone(58-18-4) IR2
17-Methyltestosterone(58-18-4) IR1
17-Methyltestosterone(58-18-4) 1H NMR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

17-Methyltestosterone, 97.0%-103.0%, 0%(58-18-4)
[Sigma Aldrich]

58-18-4(sigmaaldrich)
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