| Identification | More | [Name]
4-Fluoro-3-nitrotoluene | [CAS]
446-11-7 | [Synonyms]
3-NITRO-4-FLUOROTOLUENE
4-FLUORO-3-NITROTOLUENE
TIMTEC-BB SBB008624
1-Fluoro-4-methyl-2-nitrobenzene
2-Fluoro-5-methylnitrobenzene
4-Fluoro-3-nitrotoluene 99%
4-Fluoro-3-nitrotoluene99% | [Molecular Formula]
C7H6FNO2 | [MDL Number]
MFCD00007060 | [Molecular Weight]
155.13 | [MOL File]
446-11-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [HS Code ]
2904990090 |
| Hazard Information | Back Directory | [Description]
The molecular structure of 4-fluoro-3-nitrotoluene contains four functional groups: benzene ring, fluorine atom, nitro group and methyl group. Among them, the benzene ring is the basic structural unit of aromatic compounds, the fluorine atom has a strong electron-withdrawing property, the nitro group is a strong electron-withdrawing group, and the methyl group is an electron-donating group. 4-fluoro-3-nitrotoluene has a wide range of applications in organic synthesis, mainly as a pharmaceutical and pesticide intermediate. For example, it can be used to synthesize a variety of drugs, such as cardiovascular drugs, anti-inflammatory drugs, antibiotics, etc. In pesticides, 4-fluoro-3-nitrotoluene can prepare herbicides, fungicides, insecticides, etc. In addition, 4-fluoro-3-nitrotoluene can also be used as an intermediate in synthetic dyes, plastics, synthetic fibers, etc. In analytical chemistry, it can be used as a standard solution for titration analysis, calibration of instruments and devices, evaluation methods, working standards, quality assurance/quality control, etc. | [Uses]
4-Fluoro-3-nitrotoluene serves as an electrophile in SNAr etherification reactions and acts as a reagent for synthesizing quinoline-based diamines, including quinolin-4-yl)-N3-(4-methyl-2-nitrophenyl)-propane-1,3-diamine and N1-(7-Chloroquinolin-4-yl)-N2-(2-((4-methyl-2-nitrophenyl)amino)ethyl)ethane-1,2-diamine[1][2]. | [References]
[1]Golding, T. M., Garnie, L. F., Rabie, T., Reader, J., Birkholtz, L.-M., Wicht, K. J., & Smith, G. S. (2025). Ferrocenyl Quinoline-Benzimidazole Hybrids: A Multistage Strategy to Combat Drug-Resistant Malaria. Inorganic Chemistry, 64(31), 16152–16167. https://doi.org/10.1021/acs.inorgchem.5c02689
[2]Woiwode, T. F., Rose, C., & Wandless, T. J. (1998). A Simple and Efficient Method for the Preparation of Hindered Alkyl−Aryl Ethers. The Journal of Organic Chemistry, 63(25), 9594–9596. https://doi.org/10.1021/jo981647t
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