| Identification | More | [Name]
3-Fluorobenzyl alcohol | [CAS]
456-47-3 | [Synonyms]
3-FLUOROBENZYL ALCOHOL
M-FLUOROBENZYL ALCOHOL
RARECHEM AL BD 0054
(3-Fluorophenyl)methanol
Benzyl alcohol, m-fluoro-
3-Fluorobenzylalcohol,98%
Benzenemethanol, 3-fluoro-
3-Fluorobenzyl alcohol 98%
META-FLUOROBENZYLALCOHOL
FLUOROBENZYL ALCOHOL
3-Fluorobenzenemethanol | [EINECS(EC#)]
207-265-3 | [Molecular Formula]
C7H7FO | [MDL Number]
MFCD00004631 | [Molecular Weight]
126.13 | [MOL File]
456-47-3.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless liquid | [Melting point ]
115-119 °C | [Boiling point ]
104-105 °C/22 mmHg (lit.) | [density ]
1.164 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.513(lit.)
| [Fp ]
195 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
14.09±0.10(Predicted) | [color ]
Clear colorless | [Specific Gravity]
1.164 | [BRN ]
2242511 | [InChI]
1S/C7H7FO/c8-7-3-1-2-6(4-7)5-9/h1-4,9H,5H2 | [InChIKey]
QDHRSLFSDGCJFX-UHFFFAOYSA-N | [SMILES]
OCc1cccc(F)c1 | [CAS DataBase Reference]
456-47-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenemethanol, 3-fluoro-(456-47-3) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,C | [Risk Statements ]
R14:Reacts violently with water.
R34:Causes burns.
R36/37:Irritating to eyes and respiratory system . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29062900 | [Storage Class]
10 - Combustible liquids |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
3-Fluorobenzyl alcohol was used as substrate to study pH dependence of aryl-alcohol oxidase activity. | [Definition]
ChEBI: 3-fluorobenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol substituted by a fluoro group at position 3. It is a member of monofluorobenzenes and a member of benzyl alcohols. | [General Description]
3-Fluorobenzyl alcohol undergoes acetylation reaction with acetic anhydride catalyzed by tribromo melamine to yield 3-fluorobenzyl acetate. | [Synthesis]
GENERAL STEPS: Prior to use, 0.05 g of 5 wt% Pt/C catalyst was pretreated in a stream of hydrogen at 673 K for 2 hours. Subsequently, the pretreated catalyst was mixed with 20 mL of solvent (e.g., ethanol) and the mixture was transferred to a 100 mL high-pressure reactor. After filling the reactor with hydrogen at 4.0 MPa, the reaction was initiated and hydrogenation was carried out at a set temperature. The reaction was terminated after reaching a predetermined time, and the products were analyzed by a gas chromatograph (GC-2014, Shimadzu Co.) equipped with a capillary column (DM-WAX, 30 m × 0.32 mm × 0.25 μm) coupled with a flame ionization detector (FID). | [References]
[1] Tetrahedron Letters, 1991, vol. 32, # 9, p. 1199 - 1202
[2] Organic Letters, 2007, vol. 9, # 15, p. 2791 - 2793
[3] Tetrahedron, 2008, vol. 64, # 51, p. 11783 - 11788
[4] Advanced Synthesis and Catalysis, 2014, vol. 356, # 5, p. 1093 - 1097
[5] Organic Letters, 2007, vol. 9, # 26, p. 5429 - 5432 |
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