| Identification | More | [Name]
Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine | [CAS]
4719-04-4 | [Synonyms]
1,3,5-triazine-1,3,5(2h,4h,6h)-triethanol
1,3,5-Tris(2-hydroxyethyl)hexahydro-1,3,5-triazine
HEXAHYDRO-1,3,5-TRIS(2-HYDROXYETHYL)-TRIAZINE
HEXAHYDRO-1,3,5-TRIS(HYDROXYETHYL)-S-TRIAZINE
HEXAHYDRO-1,3,5-TRIS(HYDROXYETHYL)TRIAZINE
2,2’,2’’-(hexahydro-1,3,5-triazine-1,3,5-triyl)triethanol
actane
busan1060
eta75
grotanb
grotanbk
kalpurte
km200(alcohol)
onyxide200
roksolt1-7
s-triazine-1,3,5(2h,4h,6h)-triethanol
1,3,5-tris-(2-Hydroxyethyl)hexahydro triazine
Trizin
Triadine10
1,3,5-Tris(2-hydroxyethyl) hexahydro-s-triazine | [EINECS(EC#)]
225-208-0 | [Molecular Formula]
C9H21N3O3 | [MDL Number]
MFCD01678788 | [Molecular Weight]
219.28 | [MOL File]
4719-04-4.mol |
| Chemical Properties | Back Directory | [Boiling point ]
360.1°C (rough estimate) | [density ]
1.1269 (rough estimate) | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.4830 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Ethyl Acetate (Slightly, Sonicated), Water (Slightly) | [form ]
Oil to Low-Melting Solid | [pka]
14.16±0.10(Predicted) | [color ]
Off-White to Yellow | [Water Solubility ]
Soluble (>=1 g/100 mL at 24 ºC) | [Cosmetics Ingredients Functions]
SKIN CONDITIONING
SKIN PROTECTING | [InChI]
InChI=1S/C9H21N3O3/c13-4-1-10-7-11(2-5-14)9-12(8-10)3-6-15/h13-15H,1-9H2 | [Contact allergens]
Grotan BK is a triazine derivative contained as a bio cide in cutting fluids. It is a formaldehyde releaser.
Dermatitis, delayed-type allergic conjunctivitis, and
asthma were described. | [InChIKey]
HUHGPYXAVBJSJV-UHFFFAOYSA-N | [SMILES]
N1(CCO)CN(CCO)CN(CCO)C1 | [LogP]
-2 at 24℃ | [CAS DataBase Reference]
4719-04-4(CAS DataBase Reference) | [EPA Substance Registry System]
4719-04-4(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow Solid | [General Description]
Viscous yellow liquid. | [Reactivity Profile]
HEXAHYDRO-1,3,5-TRIS(HYDROXYETHYL)-5-TRIAZINE(4719-04-4) is an amine and an alcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. | [Air & Water Reactions]
Water soluble. | [Fire Hazard]
This chemical is probably combustible. | [Description]
Grotan BK is a triazine derivative contained in cutting
fluids. It is a formaldehyde releaser.
| [Uses]
Hexahydro-l,3,5-tris-(2-hydroxyethyl)triazin is used in organic synthesis; as a bactericide in cooling fluids and various cosmetic products; formaldehyde liberator. | [Health Hazard]
Hexahydro-1,3,5-tris(hydroxyethyl)-s-triazine (TA, CAS 4719-04-4) is a widely used biocide added to water-based metalworking fluids (MWF) to control microbial populations. However, uncontrolled concentrations of this biocide within metalworking fluids may induce allergic pneumonitis. The mechanism may involve TA eliminating other competing microorganisms while simultaneously inducing the emergence of biocide-resistant mycobacteria, leading to their excessive proliferation within the fluid's sedimentation tanks [6]. Furthermore, TA rapidly releases formaldehyde in diluted aqueous solutions. This substance exhibits strong irritant and corrosive effects on rabbit skin, eyes, and upper respiratory tract, attributed to the formation of irritant formaldehyde and 2-aminoethanol. As formaldehyde is released from TA, this substance is classified as a Category 4 carcinogen alongside formaldehyde. The aerosol form of TA is classified as a Category 2 carcinogen. As no data currently exist on the systemic bioavailability of TA released through hydrolysis in tissues, nor is there experimental evidence indicating formaldehyde reaches germ cells, TA has been categorised as a Category 3B germ cell mutagen. Skin contact is not anticipated to contribute significantly to systemic toxicity[7]. | [Flammability and Explosibility]
Notclassified | [Synthesis]
General procedure for the synthesis of hydroxyethyl hexahydrohomotriazine from formaldehyde and 2-aminoethanol: To 6.1 g (0.1 mol) of 2-aminoethanol was added 3.0 g (0.1 mol as formaldehyde) of a 20 mL methanol solution of paraformaldehyde, and the mixture was stirred for 48 h at room temperature. Upon completion of the reaction, the solvent was removed by rotary evaporator and the residue was distilled under reduced pressure to give 6.3 g (86% yield) of light yellow viscous liquid. The physicochemical properties of the obtained compound (I) were in accordance with the data reported in literature [9]. | [Toxics Screening Level]
The initial threshold screening level (ITSL) for 1,3,5-triazine-1,3,5(2H,4H,6H)-triethanol (CAS
# 4719-04-4) is 0.015 μg/m3 with an annual averaging time. | [References]
[1] Helvetica Chimica Acta, 2007, vol. 90, # 9, p. 1765 - 1780
[2] Russian Journal of Applied Chemistry, 2015, vol. 88, # 7, p. 1174 - 1177
[3] Zh. Prikl. Khim. (S.-Peterburg, Russ. Fed.), 2015, vol. 88, # 7, p. 1083 - 1086,4
[4] Zhurnal Obshchei Khimii, 1953, vol. 23, p. 1771,1773; engl. Ausg. S. 1869, 1871
[5] Chemische Berichte, 1949, vol. 82, p. 316,326 |
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Energy Chemical
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China Langchem Inc.
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