| Identification | More | [Name]
2,3-Pyrazinecarboxylic anhydride | [CAS]
4744-50-7 | [Synonyms]
2,3-PYRAZINECARBOXYLIC ANHYDRIDE
2,3-PYRAZINEDICARBOXYLIC ANHYDRIDE
FURO[3,4-B]PYRAZINE-5,7-DIONE
PYRAZINE-2,3-DICARBOXYLIC ANHYDRIDE
2,3-Pyrazinedicarboxylic acid anhydride
Furo[3,4-b]pyrazine-5,7-dione (9CI)
2,3-PYRAZINEDICARBOXLIC ANHYDRIDE
2,3-PYRAZINEDICARBOXYLICANHYDRATE
5,7-Dihydrofuro[3,4-b]pyrazine-5,7-dione | [EINECS(EC#)]
225-260-4 | [Molecular Formula]
C6H2N2O3 | [MDL Number]
MFCD00179418 | [Molecular Weight]
150.09 | [MOL File]
4744-50-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
210 °C (dec.)(lit.) | [Boiling point ]
357.3±22.0 °C(Predicted) | [density ]
1.686±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Actonitrile (Slightly), DMSO | [form ]
Solid | [pka]
-3.43±0.20(Predicted) | [color ]
White to light brown crystalline powder | [InChI]
InChI=1S/C6H2N2O3/c9-5-3-4(6(10)11-5)8-2-1-7-3/h1-2H | [InChIKey]
AWJWCTOOIBYHON-UHFFFAOYSA-N | [SMILES]
C12C(=O)OC(=O)C1=NC=CN=2 | [LogP]
-0.900 (est) | [CAS DataBase Reference]
4744-50-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29349990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Crystallizes. Melting point 223-224°C (decomposes at 210°C). | [Uses]
2,?3-?Pyrazinedicarboxylic Anhydride is a reagent used in the synthesis of highly potent and selective abietane type diterpenoid amides. | [Synthesis]
Pyrazine-2,3-dicarboxylic acid (4.0 g, 23.8 mmol) was dissolved in acetic anhydride (30 mL).The reaction mixture was refluxed for one hour, and subsequently cooled down to 0 °C in ice bath.The obtained crystals of pyrazine-2,3-dicarboxylic anhydride were filtered off (yield 70%).
 | [References]
[1] Molecules, 2017, vol. 22, # 9,
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 679
[3] Helvetica Chimica Acta, 1958, vol. 41, p. 498,509 |
|
|