| Identification | More | [Name]
Ellagic acid | [CAS]
476-66-4 | [Synonyms]
2,3,7,8-tetrahydroxy(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione
2,3,7,8-TETRAHYDROXY-CHROMENO[5,4,3-CDE]CHROMENE-5,10-DIONE
4,4',5,5',6,6'-HEXAHYDROXYDIPHENIC ACID 2,6,2',6'-DILACTONE
4,4',5,5',6,6'-HEXAHYDROXYDIPHENIC ACID DILACTONE
AKOS NCG1-0028
BENZOARIC ACID
ELLAGIC ACID
TIMTEC-BB SBB006501
4,3-cde)(1)benzopyran-5,10-dione,2,3,7,8-tetrahydroxy-(1)benzopyrano(
4,3-cde][1]benzopyran-5,10-dione,2,3,7,8-tetrahydroxy-[1]-Benzopyrano[5
alizarineyellow
c.i.55005
c.i.75270
elagostasine
eleagicacid
gallogen(astringent)
lagistase
4,4,5,5-tetrahydroxybiphenyl-2,6:2,6-biscarbolactone
ellagic acid from chestnut bark
EllagicAcidDihydrate97% | [EINECS(EC#)]
207-508-3 | [Molecular Formula]
C14H6O8 | [MDL Number]
MFCD00006914 | [Molecular Weight]
302.19 | [MOL File]
476-66-4.mol |
| Chemical Properties | Back Directory | [Appearance]
cream to light yellow crystalline solid | [Melting point ]
≥350 °C
| [Boiling point ]
363.24°C (rough estimate) | [density ]
1.667 | [refractive index ]
1.5800 (estimate) | [storage temp. ]
2-8°C | [solubility ]
1 M NaOH: 10 mg/mL, dark green
| [form ]
powder
| [color ]
tan to gray
| [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents. | [Water Solubility ]
<0.1 g/100 mL at 21 ºC | [Sensitive ]
Air & Light Sensitive | [Merck ]
14,3547 | [BRN ]
47549 | [InChIKey]
AFSDNFLWKVMVRB-UHFFFAOYSA-N | [LogP]
0.239 (est) | [CAS DataBase Reference]
476-66-4(CAS DataBase Reference) | [EPA Substance Registry System]
476-66-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3
| [RTECS ]
DJ2620000
| [F ]
8-10-23 | [HS Code ]
29322000 | [Hazardous Substances Data]
476-66-4(Hazardous Substances Data) | [Toxicity]
LD50 oral in rat: > 20gm/kg |
| Hazard Information | Back Directory | [General Description]
Cream-colored needles (from pyridine) or yellow powder. Odorless. | [Reactivity Profile]
ELLAGIC ACID(476-66-4) reacts as a weak acid. Incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated. Heat is also generated by the acid-base reaction between phenols and bases. May be sulfonated exothermically very readily (for example, by concentrated sulfuric acid at room temperature). May be nitrated very rapidly, even by dilute nitric acid. | [Air & Water Reactions]
Insoluble in water. | [Fire Hazard]
Flash point data for this chemical are not available; however, ELLAGIC ACID is probably combustible. | [Chemical Properties]
cream to light yellow crystalline solid | [Application]
Ellagic acid is used in medicine and cosmetics, as an antioxidant, and has anti-cancer and anti-viral effects.
Ellagic acid, a common plant polyphenol, is an inhibitor of glutathione S-transferase with Exhibits antitumor activity. It can be used for the determination of factor XIIa in plasma. Contact activation can occur in blood coagulation. It is also used as selective, ATP-competitive inhibitor of casein kinase 2 and a Topo I and II, FGR, GSK, and PKA inhibitor. | [Uses]
Ellagic Acid is a phenol antioxidant found naturally in various fruits and vegetables. Ellagic Acid was shown to exhibit high levels of antiproliferative and antioxidant properties in studies, which s
uggests its potential health benefits following ellagic acid consumption. | [Uses]
hemostatic, antineoplastic, antimutagenic | [Definition]
ChEBI: An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables,
ncluding raspberries, strawberries, cranberries, and pomegranates. | [Preparation]
Ellagic acid is mainly extracted from plants, and it is present in several fruits such as cranberries, strawberries, raspberries, and pomegranates. Usually, the raw materials are degreasing and then extracted with an alkaline aqueous solution or extracted with ethanol. Then, after removing water-soluble proteins and gliadins, the sugar ligands can be decomposed by enzymes to obtain purer ellagic acid. | [Biological Activity]
Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC 50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk? and FGR respectively). Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutathione S-transferase. | [Biochem/physiol Actions]
Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase. Used for the assay of factor XIIa in plasma. Contact activation in blood coagulation. | [Anticancer Research]
Ellagic acid is a naturally occurring phenolic constituent present in natural productsand nuts, most elevated amounts of which are found in raspberries (Daniel et al.1990). EA is considered as a potent anticarcinogenic and antimutagenic compound.EA shows anti-angiogenic property by repressing PDGF-R movement and phosphorylationof its substrate. It can intrude with endothelial cell-associated VEGR-2phosphorylation bringing about the restraint of the downstream signaling activatedby this receptor and in the hindrance of two key events fundamental in angiogenesis,i.e., EC movement and morphogenic separation into capillary-like structure. In parallel,EA indicated robust inhibitory activity against perivascular cells through itsrestraint of PDGF-R action and signaling prompting hindrance of VSMC relocation(Labrecque et al. 2005).
It is a phenolic compound extracted from pomegranate. It is an antiproliferative andantioxidant compound (Murakami et al. 1996). It induces apoptosis in cancer cellsof the prostate and breast and prevents the process of metastasis in different cancers(Singh et al. 2016b). | [storage]
Room temperature | [Purification Methods]
This antioxidant crystallises from pyridine. It forms a dark green solution in aqueous N NaOH. The tetraactetate dilactone crystallises from Ac2O, with m 340o. [Beilstein 19 H 261, 19 III/IV 3164, 19/7 V 108.] |
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