| Identification | Back Directory | [Name]
1-HYDROXYPIPERIDINE | [CAS]
4801-58-5 | [Synonyms]
1-piperidinol
piperidin-1-ol
Hydroxypiperidine
1-HYDROXYPIPERDINE
1-HYDROXYPIPERIDINE
N-HYDROXYPIPERIDINE
1-hydroxy-piperidin
1-HYDROXYPIPERIDINE 96+%
1-Piperidinol/1-hydroxypiperidine | [EINECS(EC#)]
225-362-9 | [Molecular Formula]
C5H11NO | [MDL Number]
MFCD00038048 | [MOL File]
4801-58-5.mol | [Molecular Weight]
101.15 |
| Chemical Properties | Back Directory | [Appearance]
Soluble in water, organic solvents, aqueous acids, and bases. | [Melting point ]
37-39 °C
| [Boiling point ]
146-148℃ (1 Torr) | [density ]
0.9903 (rough estimate) | [refractive index ]
1.4550 (estimate) | [Fp ]
78 °C | [storage temp. ]
2-8°C
| [form ]
low melting solid | [pka]
14.19±0.20(Predicted) | [color ]
White | [BRN ]
102726 | [InChI]
1S/C5H11NO/c7-6-4-2-1-3-5-6/h7H,1-5H2 | [InChIKey]
LKPFBGKZCCBZDK-UHFFFAOYSA-N | [SMILES]
ON1CCCCC1 | [EPA Substance Registry System]
Piperidine, 1-hydroxy- (4801-58-5) |
| Hazard Information | Back Directory | [Uses]
Base for Fmoc-based solid phase peptide synthesis1Light stabilizing agent2 | [Chemical Properties]
Soluble in water, organic solvents, aqueous acids, and bases. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 53, p. 5856, 1988 DOI: 10.1021/jo00260a012 | [Synthesis]
General procedure for the synthesis of N-hydroxypiperidine from hexahydropyridine: hexahydropyridine (5 mmol) and ChPS (5.5 mmol) were added to a round-bottomed flask under nitrogen protection, and the reaction was stirred for 1 hr at 60 °C. After completion of the reaction, the mixture was dissolved in water (5 mL) and the product was extracted with dichloromethane or ethyl acetate (5 mL each time, 3 times). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the target product N-hydroxypiperidine. | [References]
[1] Synlett, 2017, vol. 28, # 17, p. 2315 - 2319
[2] Tetrahedron Letters, 2001, vol. 42, # 20, p. 3419 - 3422
[3] Justus Liebigs Annalen der Chemie, 1948, vol. 559, p. 1,22, 23
[4] Chemische Berichte, 1951, vol. 84, p. 690,698
[5] Chemische Berichte, 1892, vol. 25, p. 2782 |
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