| Identification | Back Directory | [Name]
Ethyl piperidine-3-carboxylate hydrochloride | [CAS]
4842-86-8 | [Synonyms]
ETHYL NIPECOTATE HYDROCHLORIDE
Ethyl 3-Piperidine-Carboxylate HCl
Ethyl piperidine-3-carboxylate HCl
ETHYL 3-PIPERIDINECARBOXYLATE HYDROCHLORIDE
3-Piperidine Carboxylic Acid Ethyl Ester HCl
Ethyl piperidine-3-carboxylate hydrochloride
Ethyl 3-piperidinecarboxylicester hydrochloride
RS-3-Piperidinecarboxylic acid ethyl ester hydrochloride | [EINECS(EC#)]
203-126-8 | [Molecular Formula]
C8H16ClNO2 | [MDL Number]
MFCD09032960 | [MOL File]
4842-86-8.mol | [Molecular Weight]
193.67 |
| Hazard Information | Back Directory | [Synthesis]
Example 171A Synthesis of 3-(ethoxycarbonyl)piperidine hydrochloride: thionyl chloride (22.5 mL) was slowly added dropwise to a solution of ethanol (40 mL) containing piperidine-3-carboxylic acid (10.7 g, 83 mmol) at 0 °C. Subsequently, the reaction mixture was heated to reflux and kept reacting overnight. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure to afford the target product 3-(ethoxycarbonyl)piperidine hydrochloride (13 g, yield: 100%). The product was analyzed by LC-MS (ESI) and showed m/z: 158 ([M+H]+). | [References]
[1] Patent: US2009/197863, 2009, A1. Location in patent: Page/Page column 80
[2] Patent: WO2018/26779, 2018, A1. Location in patent: Page/Page column 30; 31
[3] Patent: US2009/62268, 2009, A1. Location in patent: Page/Page column 47-48 |
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