| Identification | More | [Name]
(4-Hydroxy-2-methyl)phenylboronic acid | [CAS]
493035-82-8 | [Synonyms]
(4-HYDROXY-2-METHYL)BENZENEBORONIC ACID
(4-HYDROXY-2-METHYL)PHENYLBORONIC ACID
Boronic acid, (4-hydroxy-2-methylphenyl)-(9CI)
4-Borono-3-methylphenol
5-hydroxytoluene-2-boronic acid | [Molecular Formula]
C7H9BO3 | [MDL Number]
MFCD03788424 | [Molecular Weight]
151.96 | [MOL File]
493035-82-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
100-104°C | [Boiling point ]
361.4±52.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
9.17±0.58(Predicted) | [color ]
White to Almost white | [InChI]
1S/C7H9BO3/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4,9-11H,1H3 | [InChIKey]
OYIYNIONWDBJIF-UHFFFAOYSA-N | [SMILES]
Cc1cc(O)ccc1B(O)O | [CAS DataBase Reference]
493035-82-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
(4-Hydroxy-2-methylphenyl)boronic Acid is a reactant in the preparation of biarylmethoxy nicotinamides as specific inhibitors of mycobacterium tuberculosis | [Uses]
suzuki reaction | [Synthesis]
The general procedure for the synthesis of 4-hydroxy-2-methylphenylboronic acid from 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is as follows:
1. sodium periodate (2.39 g, 11.15 mmol) was added to acetone and water (2:1, 36 mL) containing 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (870.4 mg, 3.72 mmol) and ammonium acetate (859.8 mg, 11.15 mmol) in a room temperature in a mixed solution.
2. The reaction mixture was stirred for 68 hours, then filtered and concentrated. 3.
3. Sodium chloride was added to the concentrated filtrate and extracted with ethyl acetate. 4.
4. The organic layer was dried with anhydrous magnesium sulfate, followed by filtration and concentration. 5.
5. The residue was purified by silica gel chromatography using 1:4 ethyl acetate:hexane as eluent to afford 275.7 mg (49% yield) of 4-hydroxy-2-methylphenylboronic acid as a solid.
Product characterization data:
1H NMR (400 MHz, d6-DMSO): δ 9.28 (s, 1H), 7.70 (d, J = 9 Hz, 1H), 6.56-6.52 (m, 2H), 2.55 (s, 3H).
ESI-LCMS m/z 151 (M-H)-. | [References]
[1] Patent: US2008/96921, 2008, A1. Location in patent: Page/Page column 82 |
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