| Identification | Back Directory | [Name]
POLYPHYLLIN D | [CAS]
50773-41-6 | [Synonyms]
Paris I
Saponin Pa
Polyphyllin
Polyphyllin I
Polyphyllin C
Polyphillin D
Polyphyllin A
Polyphyllin Ⅰ
POLYPHYLLIN D
GLYCO-DIOSGENIN
Paris saponin Pa
Paridis saponin I
I,Chonglousaponin
POLYPHYLLIN D USP/EP/BP
Polyphyllin I(Chonglou Saponin I)
Chonglou Saponin I(Polyphyllin A)
Polyphyllin I, 98%, from Paris polyphylla Smith var.chinensis
Polyphyllin D / Diosgenyl 4-O-α-L-arabinofuranosyl-2-O-α-L-rhamnopyranosyl-β -D-glucopyranoside
β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-α-L-arabinofuranosyl-(1→4)-O-[6-deoxy-α-L-mannopyranosyl-(1→2)]- | [Molecular Formula]
C44H70O16 | [MDL Number]
MFCD12407435 | [MOL File]
50773-41-6.mol | [Molecular Weight]
855.02 |
| Chemical Properties | Back Directory | [Melting point ]
>245°C (dec.) | [density ]
1.40 | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) | [form ]
Solid | [pka]
12?+-.0.70(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Description]
Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity.1 It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 μM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells.2 Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.1 | [Chemical Properties]
White crystalline powder, easily soluble in methanol and water, derived from Paris polyphylla. | [Uses]
Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers. | [in vivo]
Polyphyllin I (1.5 mg/kg; i.p. twice daily from day 2 to day 11) significantly inhibit the tumor growth of A549 cells in the nude mice[1]. | Animal Model: | BALB/c nude mice (5 weeks old) were s.c. inoculated with A549 cells[1] | | Dosage: | 1.5 mg/kg
| | Administration: | I.p. twice daily from day 2 to day 11 | | Result: | The tumor growth rate was much lower than that in cisplatin group and PBS
group.
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| [References]
[1] MEI-SZE LEE. Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft.[J]. Cancer Biology & Therapy, 2005, 4 11: 1248-1254. DOI: 10.4161/cbt.4.11.2136
[2] ROSE C.Y. ONG . Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells[J]. Cancer letters, 2008, 261 2: Pages 158-164. DOI: 10.1016/j.canlet.2007.11.005 |
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