| Identification | Back Directory | [Name]
licarin B | [CAS]
51020-87-2 | [Synonyms]
licarin B
Licarine B
(-)-Licarin B
5-[(2S)-2,3-Dihydro-7-methoxy-3β-methyl-5-[(E)-1-propenyl]benzofuran-2-yl]-1,3-benzodioxole
5-((2R,3R)-2,3-Dihydro-7-methoxy-3-methyl-5-(1E)-1-propenyl-2-benzofuranyl)-1,3-benzodioxole
5-[(3S)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran-2-yl]-1,3-benzodioxole
1,3-Benzodioxole, 5-[(2R,3R)-2,3-dihydro-7-methoxy-3-methyl-5-(1E)-1-propen-1-yl-2-benzofuranyl]-
1,3-Benzodioxole,5-[(2R,3R)-2,3-dihydro-7-Methoxy-3-Methyl-5-(1E)-1-propenyl-2-benzofuranyl]-(9CI) | [EINECS(EC#)]
2017-001-1 | [Molecular Formula]
C20H20O4 | [MDL Number]
MFCD13195533 | [MOL File]
51020-87-2.mol | [Molecular Weight]
324.37 |
| Chemical Properties | Back Directory | [Boiling point ]
428.5±45.0 °C(Predicted) | [density ]
1.201±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [color ]
White | [InChI]
InChI=1S/C20H20O4/c1-4-5-13-8-15-12(2)19(24-20(15)18(9-13)21-3)14-6-7-16-17(10-14)23-11-22-16/h4-10,12,19H,11H2,1-3H3/b5-4+/t12-,19-/m1/s1 | [InChIKey]
DMMQXURQRMNSBM-YZAYTREXSA-N | [SMILES]
O1C2=CC=C([C@H]3[C@H](C)C4=CC(/C=C/C)=CC(OC)=C4O3)C=C2OC1 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from nutmeg, Lauraceae (Lauraceae) Licarin aritu Ducke trunk (yield: 0.35%) Machilus japonica Sieb.et Zucc. Ye Hongnan Machilus thunbergii Sieb.et Zucc. Bark, wood, leaves. | [Uses]
Licarin B has antibacterial, anti-inflammatory, sedative and anti-tumor effects. | [Biological Activity]
Licarin B, derived from the seeds of Myristica fragrans, is an inhibitor of NO production and improves insulin sensitivity by activating PPARγ and GLUT4 in the IRS-1/PI3K/AKT pathway. | [in vitro]
Licarin B (5 μM, 10 μM, 15 μM. 8 days) moderately increases TG accumulation during adipogenic differentiation and showed partial PPARg agonist activity in 3T3-L1 preadipocytes. Cell Viability Assay < /p> | Cell Line: | 3T3-L1 cell. | | Concentration: | 1-500 μM. | | Incubation Time: | 48 h. | | Result: | Did not cause significant cell death up to 500 μM concentration. | Cell Viability Assay | Cell Line: | 3T3-L1 cell. | | Concentration: | 5 μM, 10 μM, 15 μM. | | Incubation Time: | 8 days (replaced every 2 days). | 8 days (replaced every 2 days). | td> | Result: | LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation. | < span class="view_more"> | [target]
PPAR | GLUT | PI3K | Akt | IRS-1 |
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